Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats

Philip W. Landfield, Thomas A. Pitler

Research output: Contribution to journalArticlepeer-review

414 Scopus citations

Abstract

The possibility that calcium is elevated in brain neurons during aging was examined by quantifying afterhyperpolarizations induced by spike bursts in CA1 neurons of hippocampal slices from young and aged rats. The afterhyperpolarizations result from Ca2+-dependent K+ conductance increases and are blocked in medium low in Ca2+ and prolonged in medium high in Ca2+. The afterhyperpolarization and associated conductance increases were considerably prolonged in cells from aged rats, although inhibitory postsynaptic potentials did not differ with age. Since elevated intracellular Ca2+ can exert deleterious effects on neurons, the data suggest that altered Ca2+ homeostasis may play a significant role in normal brain aging.

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalScience
Volume226
Issue number4678
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • General

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