Promising molecular targets for cancer prevention: AP-1, NF-κB and Pdcd4

Matthew R. Young, Hsin Sheng Yang, Nancy H. Colburn

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations

Abstract

There are still many unanswered questions regarding the processes by which extracellular signals are transduced from plasma-membrane receptors to the transcription machinery in the nucleus and the translation machinery in the cytoplasm. Some of these gene expression events become misregulated as a result of environmental or endogenous exposure to agents that cause multistage carcinogenesis. We are now beginning to identify and validate the crucial molecular events that drive the rate-limiting steps of carcinogenesis and to target these events for cancer prevention. Transcription factors AP-1 and nuclear factor κB can be specifically targeted to prevent cancer induction in mouse models. A protein known as programmed-cell-death-4 is a new potential molecular target that has a surprising mode of action.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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