(Pro)renin receptor in the kidney: Function and significance

Gertrude Arthur, Jeffrey L. Osborn, Frederique B. Yiannikouris

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


(Pro)renin receptor (PRR), a 350-amino acid receptor initially thought of as a receptor for the binding of renin and prorenin, is multifunctional. In addition to its role in the renin-angiotensin system (RAS), PRR transduces several intracellular signaling molecules and is a component of the vacuolar Hþ-ATPase that participates in autophagy. PRR is found in the kidney and particularly in great abundance in the cortical collecting duct. In the kidney, PRR participates in water and salt balance, acid-base balance, and autophagy and plays a role in development and progression of hypertension, diabetic retinopathy, and kidney fibrosis. This review highlights the role of PRR in the development and function of the kidney, namely, the macula densa, podocyte, proximal and distal convoluted tubule, and the principal cells of the collecting duct, and focuses on PRR function in body fluid volume homeostasis, blood pressure regulation, and acid-base balance. This review also explores new advances in the molecular mechanism involving PRR in normal renal health and pathophysiological states.

Original languageEnglish
Pages (from-to)R377-R383
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number4
StatePublished - Apr 2021

Bibliographical note

Publisher Copyright:
Copyright © 2021 the American Physiological Society


  • Blood pressure
  • Kidney
  • Prorenin receptor
  • Sodium balance
  • Water balance

ASJC Scopus subject areas

  • General Medicine


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