Prospective randomized controlled trial of fetal fibronectin on preterm labor management in a tertiary care center

M. Patrick Lowe, Bridget Zimmerman, Wendy Hansen

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Objective: The purpose of this study was to investigate the effect of the rapid fetal fibronectin on the length of hospital stay and the use of preterm labor interventions in a tertiary care center. Study design: Women who were seen in the Labor and Delivery Unit with symptoms of preterm labor were assigned randomly to receive fetal fibronectin (n = 46 women) or to preterm labor management without fetal fibronectin (n = 51 women). Physicians were not blinded to the result; groups were compared. Results: There was no difference between groups in demographic or obstetric characteristics, the hours spent in labor and delivery, the number of women who were admitted to the antepartum service, the length of stay, or medical interventions. When the results for women with a negative fetal fibronectin test were compared to women with a positive fetal fibronectin test, a significant difference was found in admissions to the antepartum service (P = .032) and the length of stay (P = .008). Conclusions: A negative fetal fibronectin test was associated with fewer admissions to the antepartum ward and a shorter length of stay.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume190
Issue number2
DOIs
StatePublished - Feb 2004

Bibliographical note

Funding Information:
Supported by Process Improvement Grant, University of Iowa.

Funding Information:
FFN was collected in the following way. A Dacron swab was rolled against the posterior lip of the cervix. The collected specimen was then placed into a buffer solution and sent to the laboratory. The results were available within 1 hour. Results were reported as positive if the assay measured >50 ng/mL and negative if <50 ng/mL. This study was supported by a process improvement grant sponsored by the University of Iowa. All fFN tests were paid for by the grant.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Funding

Supported by Process Improvement Grant, University of Iowa. FFN was collected in the following way. A Dacron swab was rolled against the posterior lip of the cervix. The collected specimen was then placed into a buffer solution and sent to the laboratory. The results were available within 1 hour. Results were reported as positive if the assay measured >50 ng/mL and negative if <50 ng/mL. This study was supported by a process improvement grant sponsored by the University of Iowa. All fFN tests were paid for by the grant.

FundersFunder number
University of Northern Iowa
University of Northern Iowa

    Keywords

    • Fetal fibronectin
    • Length of stay
    • Preterm

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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