Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation

James B. Atkinson; Edward D. Gomperts; Robert Kang; Martin Lee; Robert M. Arensman; Robert H. Bartlett; K. Rais-Bharami; Charles W. Breaux; J. Devn Cornish; Gerald M. Haase; Jay Roden; Joseph B. Zwischenberger

doi:10.1016/S0002-9610(97)00018-4

Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation

James B. Atkinson, Edward D. Gomperts, Robert Kang, Martin Lee, Robert M. Arensman, Robert H. Bartlett, K. Rais-Bharami, Charles W. Breaux, J. Devn Cornish, Gerald M. Haase, Jay Roden, Joseph B. Zwischenberger

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

BACKGROUND: The topical hemostatic effect of fibrin sealant that has been solvent/detergent treated and plasminogen depleted was evaluated in a multicenter prospective, randomized controlled study at the cannulation site wound of infants undergoing extracorporeal membrane oxygenation (ECMO). METHODS: The test group received standard cauterization and Fibrin sealant, while the control group was given cauterization alone to control hemostasis at this site. Efficacy data were available on 173 randomized study subjects of whom 149 met study entry criteria. All were managed according to standard ECMO practice. RESULTS: Fibrin sealant reduced the risk of bleeding, was associated with less shed blood, and was associated with shorter duration of hemorrhage. Further, control infants showed an increased bleeding risk with less depressed fibrinogen levels and prothrombin time elevations >18 seconds prior to ECMO. CONCLUSION: Fibrin sealant is useful as a topical hemostatic agent in patients with coagulopathy not responding to standard surgical techniques.

Original language	English
Pages (from-to)	479-484
Number of pages	6
Journal	American Journal of Surgery
Volume	173
Issue number	6
DOIs	https://doi.org/10.1016/S0002-9610(97)00018-4
State	Published - Jun 1997

Bibliographical note

Funding Information:
Michigan. This research was supported by the Hyland Division, Baxter Healthcare Corporation, and the American Red Cross. We wish to acknowledge the clinical research management role of Gordon Bray, MD, and Lynn Dedrick, RN. Requests for reprints should be addressed to James B. Atkin-son, MD, UCLA Medical Center, 10833 Le Conte Ave., Box 951749, Los Angeles, California 90095-l 749. Manuscript submitted June 11, 1996 and accepted form September 3, 1996.

Funding

Michigan. This research was supported by the Hyland Division, Baxter Healthcare Corporation, and the American Red Cross. We wish to acknowledge the clinical research management role of Gordon Bray, MD, and Lynn Dedrick, RN. Requests for reprints should be addressed to James B. Atkin-son, MD, UCLA Medical Center, 10833 Le Conte Ave., Box 951749, Los Angeles, California 90095-l 749. Manuscript submitted June 11, 1996 and accepted form September 3, 1996.

Funders	Funder number
American Red Cross
Baxter Healthcare Corporation

ASJC Scopus subject areas

Surgery

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10.1016/S0002-9610(97)00018-4

Cite this

Atkinson, J. B., Gomperts, E. D., Kang, R., Lee, M., Arensman, R. M., Bartlett, R. H., Rais-Bharami, K., Breaux, C. W., Cornish, J. D., Haase, G. M., Roden, J., & Zwischenberger, J. B. (1997). Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation. American Journal of Surgery, 173(6), 479-484. https://doi.org/10.1016/S0002-9610(97)00018-4

@article{144d52518255409d987bc80a03c77428,

title = "Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation",

abstract = "BACKGROUND: The topical hemostatic effect of fibrin sealant that has been solvent/detergent treated and plasminogen depleted was evaluated in a multicenter prospective, randomized controlled study at the cannulation site wound of infants undergoing extracorporeal membrane oxygenation (ECMO). METHODS: The test group received standard cauterization and Fibrin sealant, while the control group was given cauterization alone to control hemostasis at this site. Efficacy data were available on 173 randomized study subjects of whom 149 met study entry criteria. All were managed according to standard ECMO practice. RESULTS: Fibrin sealant reduced the risk of bleeding, was associated with less shed blood, and was associated with shorter duration of hemorrhage. Further, control infants showed an increased bleeding risk with less depressed fibrinogen levels and prothrombin time elevations >18 seconds prior to ECMO. CONCLUSION: Fibrin sealant is useful as a topical hemostatic agent in patients with coagulopathy not responding to standard surgical techniques.",

author = "Atkinson, {James B.} and Gomperts, {Edward D.} and Robert Kang and Martin Lee and Arensman, {Robert M.} and Bartlett, {Robert H.} and K. Rais-Bharami and Breaux, {Charles W.} and Cornish, {J. Devn} and Haase, {Gerald M.} and Jay Roden and Zwischenberger, {Joseph B.}",

note = "Funding Information: Michigan. This research was supported by the Hyland Division, Baxter Healthcare Corporation, and the American Red Cross. We wish to acknowledge the clinical research management role of Gordon Bray, MD, and Lynn Dedrick, RN. Requests for reprints should be addressed to James B. Atkin-son, MD, UCLA Medical Center, 10833 Le Conte Ave., Box 951749, Los Angeles, California 90095-l 749. Manuscript submitted June 11, 1996 and accepted form September 3, 1996.",

year = "1997",

month = jun,

doi = "10.1016/S0002-9610(97)00018-4",

language = "English",

volume = "173",

pages = "479--484",

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Atkinson, JB, Gomperts, ED, Kang, R, Lee, M, Arensman, RM, Bartlett, RH, Rais-Bharami, K, Breaux, CW, Cornish, JD, Haase, GM, Roden, J & Zwischenberger, JB 1997, 'Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation', American Journal of Surgery, vol. 173, no. 6, pp. 479-484. https://doi.org/10.1016/S0002-9610(97)00018-4

Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation. / Atkinson, James B.; Gomperts, Edward D.; Kang, Robert et al.
In: American Journal of Surgery, Vol. 173, No. 6, 06.1997, p. 479-484.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation

AU - Atkinson, James B.

AU - Gomperts, Edward D.

AU - Kang, Robert

AU - Lee, Martin

AU - Arensman, Robert M.

AU - Bartlett, Robert H.

AU - Rais-Bharami, K.

AU - Breaux, Charles W.

AU - Cornish, J. Devn

AU - Haase, Gerald M.

AU - Roden, Jay

AU - Zwischenberger, Joseph B.

N1 - Funding Information: Michigan. This research was supported by the Hyland Division, Baxter Healthcare Corporation, and the American Red Cross. We wish to acknowledge the clinical research management role of Gordon Bray, MD, and Lynn Dedrick, RN. Requests for reprints should be addressed to James B. Atkin-son, MD, UCLA Medical Center, 10833 Le Conte Ave., Box 951749, Los Angeles, California 90095-l 749. Manuscript submitted June 11, 1996 and accepted form September 3, 1996.

PY - 1997/6

Y1 - 1997/6

N2 - BACKGROUND: The topical hemostatic effect of fibrin sealant that has been solvent/detergent treated and plasminogen depleted was evaluated in a multicenter prospective, randomized controlled study at the cannulation site wound of infants undergoing extracorporeal membrane oxygenation (ECMO). METHODS: The test group received standard cauterization and Fibrin sealant, while the control group was given cauterization alone to control hemostasis at this site. Efficacy data were available on 173 randomized study subjects of whom 149 met study entry criteria. All were managed according to standard ECMO practice. RESULTS: Fibrin sealant reduced the risk of bleeding, was associated with less shed blood, and was associated with shorter duration of hemorrhage. Further, control infants showed an increased bleeding risk with less depressed fibrinogen levels and prothrombin time elevations >18 seconds prior to ECMO. CONCLUSION: Fibrin sealant is useful as a topical hemostatic agent in patients with coagulopathy not responding to standard surgical techniques.

AB - BACKGROUND: The topical hemostatic effect of fibrin sealant that has been solvent/detergent treated and plasminogen depleted was evaluated in a multicenter prospective, randomized controlled study at the cannulation site wound of infants undergoing extracorporeal membrane oxygenation (ECMO). METHODS: The test group received standard cauterization and Fibrin sealant, while the control group was given cauterization alone to control hemostasis at this site. Efficacy data were available on 173 randomized study subjects of whom 149 met study entry criteria. All were managed according to standard ECMO practice. RESULTS: Fibrin sealant reduced the risk of bleeding, was associated with less shed blood, and was associated with shorter duration of hemorrhage. Further, control infants showed an increased bleeding risk with less depressed fibrinogen levels and prothrombin time elevations >18 seconds prior to ECMO. CONCLUSION: Fibrin sealant is useful as a topical hemostatic agent in patients with coagulopathy not responding to standard surgical techniques.

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ER -

Prospective, randomized evaluation of the efficacy of fibrin sealant as a topical hemostatic agent at the cannulation site in neonates undergoing extracorporeal membrane oxygenation

Abstract

Bibliographical note

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ASJC Scopus subject areas

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