Prospects for therapeutic mitochondrial transplantation

Jenna L. Gollihue, Alexander G. Rabchevsky

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Mitochondrial dysfunction has been implicated in a multitude of diseases and pathological conditions- the organelles that are essential for life can also be major players in contributing to cell death and disease. Because mitochondria are so well established in our existence, being present in all cell types except for red blood cells and having the responsibility of providing most of our energy needs for survival, then dysfunctional mitochondria can elicit devastating cellular pathologies that can be widespread across the entire organism. As such, the field of “mitochondrial medicine” is emerging in which disease states are being targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. New and compelling research investigating novel techniques for mitochondrial transplantation to replace damaged or dysfunctional mitochondria with exogenous healthy mitochondria has shown promising results, including tissue sparing accompanied by increased energy production and decreased oxidative damage. Various experimental techniques have been attempted and each has been challenged to accomplish successful transplantation. The purpose of this review is to present the history of mitochondrial transplantation, the different techniques used for both in vitro and in vivo delivery, along with caveats and pitfalls that have been discovered along the way. Results from such pioneering studies are promising and could be the next big wave of “mitochondrial medicine” once technical hurdles are overcome.

Original languageEnglish
Pages (from-to)70-79
Number of pages10
JournalMitochondrion
Volume35
DOIs
StatePublished - Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V. and Mitochondria Research Society

Keywords

  • Bioenergetics
  • Cellular uptake
  • Oxidative phosphorylation
  • Oxygen consumption
  • Replacement strategies

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Prospects for therapeutic mitochondrial transplantation'. Together they form a unique fingerprint.

Cite this