Prostaglandin photoaffinity probes: Synthesis and binding affinity of an azide-substituted 17-phenyl PGE2 prostaglandin

K. Kawada, E. Pralong, M. F. Vesin, T. A. Fitz, D. S. Watt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

(15S)-17-(4-Azidophenyl)-18,19,20-trinorprostaglandin E2 was synthesized as a photoaffinity probe using a variant of the Corey synthesis and exhibited an IC50 of 300 nM in a PGE2 receptor assay using chicken spinal cord.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalEicosanoids
Volume4
Issue number1
StatePublished - 1991

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

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