Prostaglandin photoaffinity probes: Synthesis and binding affinity of an azide-substituted 17-phenyl PGE2 prostaglandin

K. Kawada; E. Pralong; M. F. Vesin; T. A. Fitz; D. S. Watt

Prostaglandin photoaffinity probes: Synthesis and binding affinity of an azide-substituted 17-phenyl PGE₂ prostaglandin

K. Kawada
, E. Pralong
, M. F. Vesin
, T. A. Fitz
, D. S. Watt

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

(15S)-17-(4-Azidophenyl)-18,19,20-trinorprostaglandin E₂ was synthesized as a photoaffinity probe using a variant of the Corey synthesis and exhibited an IC₅₀ of 300 nM in a PGE₂ receptor assay using chicken spinal cord.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	Eicosanoids
Volume	4
Issue number	1
State	Published - 1991

Funding

Funders	Funder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development	R01HD025961

ASJC Scopus subject areas

Pharmacology
Biochemistry

Cite this

@article{17f440f73a734e3ea216d3408d90e7dc,

title = "Prostaglandin photoaffinity probes: Synthesis and binding affinity of an azide-substituted 17-phenyl PGE2 prostaglandin",

abstract = "(15S)-17-(4-Azidophenyl)-18,19,20-trinorprostaglandin E2 was synthesized as a photoaffinity probe using a variant of the Corey synthesis and exhibited an IC50 of 300 nM in a PGE2 receptor assay using chicken spinal cord.",

author = "K. Kawada and E. Pralong and Vesin, \{M. F.\} and Fitz, \{T. A.\} and Watt, \{D. S.\}",

year = "1991",

language = "English",

volume = "4",

pages = "57--60",

number = "1",

}

TY - JOUR

T1 - Prostaglandin photoaffinity probes

T2 - Synthesis and binding affinity of an azide-substituted 17-phenyl PGE2 prostaglandin

AU - Kawada, K.

AU - Pralong, E.

AU - Vesin, M. F.

AU - Fitz, T. A.

AU - Watt, D. S.

PY - 1991

Y1 - 1991

N2 - (15S)-17-(4-Azidophenyl)-18,19,20-trinorprostaglandin E2 was synthesized as a photoaffinity probe using a variant of the Corey synthesis and exhibited an IC50 of 300 nM in a PGE2 receptor assay using chicken spinal cord.

AB - (15S)-17-(4-Azidophenyl)-18,19,20-trinorprostaglandin E2 was synthesized as a photoaffinity probe using a variant of the Corey synthesis and exhibited an IC50 of 300 nM in a PGE2 receptor assay using chicken spinal cord.

UR - https://www.scopus.com/pages/publications/0026088958

UR - https://www.scopus.com/pages/publications/0026088958#tab=citedBy

M3 - Article

C2 - 2059459

AN - SCOPUS:0026088958

SN - 0934-9820

VL - 4

SP - 57

EP - 60

JO - Eicosanoids

JF - Eicosanoids

IS - 1

ER -

Prostaglandin photoaffinity probes: Synthesis and binding affinity of an azide-substituted 17-phenyl PGE₂ prostaglandin

Abstract

Funding

ASJC Scopus subject areas

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