Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling

Assumpta C. Nwaneri; Lucien McBeth; Terry D. Hinds

doi:10.1007/s12672-016-0271-4

Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling

Assumpta C. Nwaneri
, Lucien McBeth
, Terry D. Hinds

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Prostate cancer (PC) is one of the leading causes of mortality amongst elderly men in the USA and is second only to lung cancer. African Americans (AA) are at an increased risk of developing PC and are more likely to die from the disease in comparison to Caucasian Americans (CA). Chromosomal alterations or genetic differences between AA and CA may account for the variances observed in PC progression. Importantly, mutations in the androgen receptor (AR) or the epidermal growth factor receptor (EGFR) may contribute to the disparity. Current studies are investigating the role of small nucleotide polymorphisms (SNPs) and microRNAs (miRNAs), which affect protein translation of the receptors by regulation of the 3′ untranslated region (UTR), which may enhance the progression of PC. However, these genetic differences have not been fully explored in prostates between the two ethnic groups. This review will highlight the current studies on the EGFR signaling pathway as well as the involvement of SNPs and miRNAs and relate them to variances observed in PC of AA and CA men. With an understanding of these differences, specific preventive and therapeutic strategies may be developed to target personalized medicine for prostate carcinogenesis.

Original language	English
Pages (from-to)	296-304
Number of pages	9
Journal	Hormones and Cancer
Volume	7
Issue number	5-6
DOIs	https://doi.org/10.1007/s12672-016-0271-4
State	Published - Dec 1 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.

Funding

This work was supported by the University of Toledo deArce-Memorial Endowment Fund (T.D.H). Research reported in this publication was also supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number K01HL125445 (T.D.H.) and L32MD009154 (T.D.H.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funders	Funder number
University of Toledo deArce-Memorial Endowment Fund
National Institutes of Health (NIH)	L32MD009154
National Heart, Lung, and Blood Institute (NHLBI)	K01HL125445

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Endocrine and Autonomic Systems
Cancer Research

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10.1007/s12672-016-0271-4

Cite this

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title = "Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling",

abstract = "Prostate cancer (PC) is one of the leading causes of mortality amongst elderly men in the USA and is second only to lung cancer. African Americans (AA) are at an increased risk of developing PC and are more likely to die from the disease in comparison to Caucasian Americans (CA). Chromosomal alterations or genetic differences between AA and CA may account for the variances observed in PC progression. Importantly, mutations in the androgen receptor (AR) or the epidermal growth factor receptor (EGFR) may contribute to the disparity. Current studies are investigating the role of small nucleotide polymorphisms (SNPs) and microRNAs (miRNAs), which affect protein translation of the receptors by regulation of the 3′ untranslated region (UTR), which may enhance the progression of PC. However, these genetic differences have not been fully explored in prostates between the two ethnic groups. This review will highlight the current studies on the EGFR signaling pathway as well as the involvement of SNPs and miRNAs and relate them to variances observed in PC of AA and CA men. With an understanding of these differences, specific preventive and therapeutic strategies may be developed to target personalized medicine for prostate carcinogenesis.",

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AU - McBeth, Lucien

AU - Hinds, Terry D.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Prostate cancer (PC) is one of the leading causes of mortality amongst elderly men in the USA and is second only to lung cancer. African Americans (AA) are at an increased risk of developing PC and are more likely to die from the disease in comparison to Caucasian Americans (CA). Chromosomal alterations or genetic differences between AA and CA may account for the variances observed in PC progression. Importantly, mutations in the androgen receptor (AR) or the epidermal growth factor receptor (EGFR) may contribute to the disparity. Current studies are investigating the role of small nucleotide polymorphisms (SNPs) and microRNAs (miRNAs), which affect protein translation of the receptors by regulation of the 3′ untranslated region (UTR), which may enhance the progression of PC. However, these genetic differences have not been fully explored in prostates between the two ethnic groups. This review will highlight the current studies on the EGFR signaling pathway as well as the involvement of SNPs and miRNAs and relate them to variances observed in PC of AA and CA men. With an understanding of these differences, specific preventive and therapeutic strategies may be developed to target personalized medicine for prostate carcinogenesis.

AB - Prostate cancer (PC) is one of the leading causes of mortality amongst elderly men in the USA and is second only to lung cancer. African Americans (AA) are at an increased risk of developing PC and are more likely to die from the disease in comparison to Caucasian Americans (CA). Chromosomal alterations or genetic differences between AA and CA may account for the variances observed in PC progression. Importantly, mutations in the androgen receptor (AR) or the epidermal growth factor receptor (EGFR) may contribute to the disparity. Current studies are investigating the role of small nucleotide polymorphisms (SNPs) and microRNAs (miRNAs), which affect protein translation of the receptors by regulation of the 3′ untranslated region (UTR), which may enhance the progression of PC. However, these genetic differences have not been fully explored in prostates between the two ethnic groups. This review will highlight the current studies on the EGFR signaling pathway as well as the involvement of SNPs and miRNAs and relate them to variances observed in PC of AA and CA men. With an understanding of these differences, specific preventive and therapeutic strategies may be developed to target personalized medicine for prostate carcinogenesis.

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Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

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