Protection against lipopolysaccharide-induced death by fluoroquinolones

A. A. Khan, T. R. Slifer, F. G. Araujo, Y. Suzuki, J. S. Remington

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100 mg/kg), ciprofloxacin (250 mg/kg), and tosufloxacin (100 mg/kg) protected 75% (P = 0.0001), 25% (P = 0.002), and 50% (P = 0.002), respectively, of mice against death. The fluoroquinolones significantly reduced serum levels of interleukin-6 and tumor necrosis factor alpha in LPS-treated mice. The protective effects of fluoroquinolones in LPS-induced shock in mice may also occur in humans.

Original languageEnglish
Pages (from-to)3169-3173
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number11
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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