TY - JOUR
T1 - Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus
AU - Brien, James D.
AU - Sukupolvi-Petty, Soila
AU - Williams, Katherine L.
AU - Lam, Chia Ying Kao
AU - Schmid, Michael A.
AU - Johnson, Syd
AU - Harris, Eva
AU - Diamond, Michael S.
PY - 2013/7
Y1 - 2013/7
N2 - Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ~ 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.
AB - Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ~ 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.
UR - http://www.scopus.com/inward/record.url?scp=84880385914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880385914&partnerID=8YFLogxK
U2 - 10.1128/JVI.00327-13
DO - 10.1128/JVI.00327-13
M3 - Article
C2 - 23658441
AN - SCOPUS:84880385914
SN - 0022-538X
VL - 87
SP - 7747
EP - 7753
JO - Journal of Virology
JF - Journal of Virology
IS - 13
ER -
