Protection of dietary polyphenols against oral cancer

Yijian Ding, Hua Yao, Yanan Yao, Leonard Yenwong Fai, Zhuo Zhang

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.

Original languageEnglish
Pages (from-to)2173-2191
Number of pages19
Issue number6
StatePublished - Jun 14 2013


  • (-)-epigallocatechin-3-gallate
  • Cancer prevention
  • Cancer therapy
  • Cell death
  • Cell growth
  • Cell migration and invasion
  • Dietary polyphenols
  • Oral cancer
  • Tea polyphenols

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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