TY - JOUR
T1 - Protection of dietary polyphenols against oral cancer
AU - Ding, Yijian
AU - Yao, Hua
AU - Yao, Yanan
AU - Fai, Leonard Yenwong
AU - Zhang, Zhuo
PY - 2013/6/14
Y1 - 2013/6/14
N2 - Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
AB - Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
KW - (-)-epigallocatechin-3-gallate
KW - Cancer prevention
KW - Cancer therapy
KW - Cell death
KW - Cell growth
KW - Cell migration and invasion
KW - Dietary polyphenols
KW - Oral cancer
KW - Tea polyphenols
UR - https://www.scopus.com/pages/publications/84879166031
UR - https://www.scopus.com/inward/citedby.url?scp=84879166031&partnerID=8YFLogxK
U2 - 10.3390/nu5062173
DO - 10.3390/nu5062173
M3 - Review article
C2 - 23771133
AN - SCOPUS:84879166031
SN - 2072-6643
VL - 5
SP - 2173
EP - 2191
JO - Nutrients
JF - Nutrients
IS - 6
ER -
