Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes

F. Di Domenico, Marzia Perluigi, C. Foppoli, C. Blarzino, R. Coccia, F. De Marco, D. A. Butterfield, C. Cini

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

UV solar radiation is the major environmental risk factor for malignant melanoma. A great effort is currently posed on the search of new compounds able to prevent or reduce UV-mediated cell damage. Ferulic acid is a natural compound recently included in the formulation of solar protecting dermatological products. The purpose of the present work was to assess whether its ethyl ester derivative, FAEE, could protect skin melanocytes from UV-induced oxidative stress and cell damage. Experiments on human melanocytes irradiated with UVB showed that FAEE treatment reduced the generation of ROS, with a net decrease of protein oxidation. FAEE treatment was accompanied by an induction of HSP70 and heme oxygenase, by a marked suppression of PARP activation and a significant suppression of apoptosis. Moreover FAEE prevented iNOS induction, thus suppressing the secondary generation of NO-derived oxidizing agents. FAEE may represent a potentially effective pharmacological approach to reduce UV radiation-induced skin damage.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalFree Radical Research
Volume43
Issue number4
DOIs
StatePublished - 2009

Bibliographical note

Funding Information:
This work was partially supported by grant of the Italian Ministry of Health. We wish to thank Dr Daniela Di Sciullo and Mr Vincenzo Peresempio for their excellent technical work. D. A. B. was supported by grants from the National Institutes of Health (USA).

Keywords

  • Heme oxygenase-1
  • Melanocytes
  • Oxidative stress
  • UVB

ASJC Scopus subject areas

  • Biochemistry

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