Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks

Jessie B. Hoffman, Bernhard Hennig

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Human exposures to environmental contaminants around the world contribute to the global burden of disease and thus require urgent attention. Exploring preventive measures against environmental exposure and disease risk is essential. While a sedentary lifestyle and/or poor dietary habits can exacerbate the deleterious effects resulting from exposure to toxic chemicals, much emerging evidence suggests that positive lifestyle changes (e.g., healthful nutrition) can modulate and/or reduce the toxicity of environmental pollutants. Our work has shown that diets high in anti-inflammatory bioactive food components (e.g., phytochemicals or polyphenols) are possible strategies for modulating and reducing the disease risks associated with exposure to toxic pollutants in the environment. Thus, consuming healthy diets rich in plant-derived bioactive nutrients may reduce the vulnerability to diseases linked to environmental toxic insults. This nutritional paradigm in environmental toxicology requires further study in order to improve our understanding of the relationships between nutrition and other lifestyle modifications and toxicant-induced diseases.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 New York Academy of Sciences.


  • anti-inflammatory nutrients
  • antioxidants
  • environmental pollutants
  • nutrition

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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