TY - JOUR
T1 - Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
AU - Hunter, Randy L.
AU - Choi, Dong Young
AU - Ross, Stuart A.
AU - Bing, Guoying
PY - 2008/2/27
Y1 - 2008/2/27
N2 - We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-γ, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-γ, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes.
AB - We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-γ, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-γ, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes.
KW - Inflammation
KW - MitoNEET
KW - PPAR-γ
KW - Parkinson's disease
KW - UCP-2
UR - http://www.scopus.com/inward/record.url?scp=39149116014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39149116014&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2007.12.019
DO - 10.1016/j.neulet.2007.12.019
M3 - Article
C2 - 18207323
AN - SCOPUS:39149116014
VL - 432
SP - 198
EP - 201
IS - 3
ER -