Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats

Randy L. Hunter, Dong Young Choi, Stuart A. Ross, Guoying Bing

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-γ, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-γ, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalNeuroscience Letters
Volume432
Issue number3
DOIs
StatePublished - Feb 27 2008

Keywords

  • Inflammation
  • MitoNEET
  • PPAR-γ
  • Parkinson's disease
  • UCP-2

ASJC Scopus subject areas

  • Neuroscience (all)

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