Protein Carbonylation in Brains of Subjects with Selected Neurodegenerative Disorders

Tanea T. Reed, D. Allan Butterfield

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


This chapter highlights the pivotal role protein carbonylation plays in selective neurodegenerative disorders including Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS). Reactive oxygen species (ROS) levels increase as a function of age and are even higher in age-related neurodegenerative disorders. It has been well established that oxidative stress is elevated in AD, PD, ALS, Huntington disease, and other neurodegenerative and psychiatric disorders such as depression, schizophrenia, bipolar disorder, and potentially autism. AD, the most common form of dementia, is a neurodegenerative disease currently affecting over five million people in the United States and 26 million people worldwide. AD has at least three stages: mild cognitive impairment (MCI), early-stage Alzheimer disease (EAD), and late-stage Alzheimer disease (LAD). The chapter focuses on PD as work regarding protein carbonylation. It explains the notion that protein carbonylation plays a pivotal role in causing protein dysfunction, thereby promoting neurodegeneration.

Original languageEnglish
Title of host publicationProtein Carbonylation
Subtitle of host publicationPrinciples, Analysis, and Biological Implications
Number of pages39
ISBN (Electronic)9781119374947
StatePublished - Apr 20 2017


  • Alzheimer disease
  • Amyotrophic lateral sclerosis
  • Cognitive impairment
  • Oxidative stress
  • Parkinson disease
  • Protein carbonylation
  • Protein dysfunction
  • Reactive oxygen species

ASJC Scopus subject areas

  • Chemistry (all)


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