TY - JOUR
T1 - Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease
T2 - Insights into mechanism of neurodegeneration from redox proteomics
AU - Sultana, Rukhsana
AU - Perluigi, Marzia
AU - Butterfield, D. Allan
PY - 2006
Y1 - 2006
N2 - Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and extracellular senile plaques. Although the initiating causes leading to AD are unknown, a number of previous studies reported the role of oxidative stress in AD brain. Postmortem analysis of AD brain showed elevated markers of oxidative stress including protein nitrotyrosine, carbonyls in proteins, lipid oxidation products, and oxidized DNA bases. In this review, we focus our attention on the role of protein oxidation and lipid peroxidation in the pathogenesis of AD. Particular attention is given to the current knowledge about the redox proteomics identification of oxidatively modified proteins in AD brain.
AB - Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and extracellular senile plaques. Although the initiating causes leading to AD are unknown, a number of previous studies reported the role of oxidative stress in AD brain. Postmortem analysis of AD brain showed elevated markers of oxidative stress including protein nitrotyrosine, carbonyls in proteins, lipid oxidation products, and oxidized DNA bases. In this review, we focus our attention on the role of protein oxidation and lipid peroxidation in the pathogenesis of AD. Particular attention is given to the current knowledge about the redox proteomics identification of oxidatively modified proteins in AD brain.
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U2 - 10.1089/ars.2006.8.2021
DO - 10.1089/ars.2006.8.2021
M3 - Review article
C2 - 17034347
AN - SCOPUS:33947644871
SN - 1523-0864
VL - 8
SP - 2021
EP - 2037
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 11-12
ER -