Background: Phosphorylation of 4E-BP1 plays a critical role in controlling its ability to inhibit protein translation. Results: PPM1G is identified as a protein phosphatase that dephosphorylates 4E-BP1 in vitro and in cells. Conclusion: PPM1G negatively regulates protein translation by controlling the phosphorylation of 4E-BP1. Significance: PPM1G-mediated dephosphorylation of 4E-BP1 provides a novel mechanism in the regulation of protein translation.
|Number of pages||9|
|Journal||Journal of Biological Chemistry|
|State||Published - Aug 9 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology