TY - JOUR
T1 - Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1)
AU - Liu, Jianyu
AU - Stevens, Payton D.
AU - Eshleman, Nichole E.
AU - Gao, Tianyan
PY - 2013/8/9
Y1 - 2013/8/9
N2 - Background: Phosphorylation of 4E-BP1 plays a critical role in controlling its ability to inhibit protein translation. Results: PPM1G is identified as a protein phosphatase that dephosphorylates 4E-BP1 in vitro and in cells. Conclusion: PPM1G negatively regulates protein translation by controlling the phosphorylation of 4E-BP1. Significance: PPM1G-mediated dephosphorylation of 4E-BP1 provides a novel mechanism in the regulation of protein translation.
AB - Background: Phosphorylation of 4E-BP1 plays a critical role in controlling its ability to inhibit protein translation. Results: PPM1G is identified as a protein phosphatase that dephosphorylates 4E-BP1 in vitro and in cells. Conclusion: PPM1G negatively regulates protein translation by controlling the phosphorylation of 4E-BP1. Significance: PPM1G-mediated dephosphorylation of 4E-BP1 provides a novel mechanism in the regulation of protein translation.
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U2 - 10.1074/jbc.M113.492371
DO - 10.1074/jbc.M113.492371
M3 - Article
C2 - 23814053
AN - SCOPUS:84881445282
SN - 0021-9258
VL - 288
SP - 23225
EP - 23233
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -