Proteoglycan mediated lipoprotein retention: A mechanism of diabetic atherosclerosis

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgenic mouse models and molecular biology techniques have added to our understanding of atherosclerosis development, and provided experimental data in support of the response to retention hypothesis. In this review we summarize the recent data, in particular that which addresses mechanisms by which diabetes can accelerate atherosclerosis formation, with a focus on proteoglycan-mediated LDL retention.

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalReviews in Endocrine and Metabolic Disorders
Issue number4
StatePublished - Dec 2008


  • Atherosclerosis
  • Cardiovascular disease
  • Extracellular matrix
  • Lipoproteins
  • Proteoglycans

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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