TY - JOUR
T1 - Proteoglycan mediated lipoprotein retention
T2 - A mechanism of diabetic atherosclerosis
AU - Tannock, Lisa R.
AU - King, Victoria L.
PY - 2008/12
Y1 - 2008/12
N2 - The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgenic mouse models and molecular biology techniques have added to our understanding of atherosclerosis development, and provided experimental data in support of the response to retention hypothesis. In this review we summarize the recent data, in particular that which addresses mechanisms by which diabetes can accelerate atherosclerosis formation, with a focus on proteoglycan-mediated LDL retention.
AB - The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgenic mouse models and molecular biology techniques have added to our understanding of atherosclerosis development, and provided experimental data in support of the response to retention hypothesis. In this review we summarize the recent data, in particular that which addresses mechanisms by which diabetes can accelerate atherosclerosis formation, with a focus on proteoglycan-mediated LDL retention.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Extracellular matrix
KW - Lipoproteins
KW - Proteoglycans
UR - http://www.scopus.com/inward/record.url?scp=54949159199&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54949159199&partnerID=8YFLogxK
U2 - 10.1007/s11154-008-9078-0
DO - 10.1007/s11154-008-9078-0
M3 - Review article
C2 - 18584330
AN - SCOPUS:54949159199
SN - 1389-9155
VL - 9
SP - 289
EP - 300
JO - Reviews in Endocrine and Metabolic Disorders
JF - Reviews in Endocrine and Metabolic Disorders
IS - 4
ER -
