Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study

Rukhsana Sultana, Tanea Reed, Marzia Perluigi, Rafaella Coccia, William M. Pierce, D. Allan Butterfield

Research output: Contribution to journalArticlepeer-review

86 Citations (SciVal)

Abstract

Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.

Original languageEnglish
Pages (from-to)839-851
Number of pages13
JournalJournal of Cellular and Molecular Medicine
Volume11
Issue number4
DOIs
StatePublished - Jul 2007

Keywords

  • Hippocampus
  • Inferior parietal lobule
  • Mild cognitive impairment
  • Oxidative stress
  • Protein nitration
  • Redox proteomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

Fingerprint

Dive into the research topics of 'Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study'. Together they form a unique fingerprint.

Cite this