Proteomics in Alzheimer's disease: Insights into potential mechanisms of neurodegeneration

D. Allan Butterfield, Debra Boyd-Kimball, Alessandra Castegna

Research output: Contribution to journalReview articlepeer-review

168 Scopus citations


Proteomics involves the identification of unknown proteins following their separation, often using two-dimensional electrophoresis, digestion of particular proteins of interest by trypsin, determination of the molecular weight of the resulting peptides, and database searching to make the identification of the proteins. Application of proteomics to Alzheimer's disease (AD), the major dementing disorder of the elderly, has just begun. Differences in protein expression and post-translational modification (mostly oxidative modification) of proteins from AD brain and peripheral tissue, as well as in brain from rodent models of AD, have yielded insights into potential molecular mechanisms of neurodegeneration in this dementing disorder. This review surveys the proteomics studies relevant to AD, from which new understandings of the pathology, biochemistry, and physiology of AD are beginning to emerge.

Original languageEnglish
Pages (from-to)1313-1327
Number of pages15
JournalJournal of Neurochemistry
Issue number6
StatePublished - Sep 2003


  • Alzheimer's disease
  • Mechanisms of neurodegeneration
  • Oxidative stress
  • Oxidatively modified proteins
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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