Proteomics in animal models of Alzheimer's and Parkinson's diseases

Renã A. Sowell, Joshua B. Owen, D. Allan Butterfield

Research output: Contribution to journalShort surveypeer-review

71 Scopus citations

Abstract

The risk of developing neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) increases with age. AD and PD are the two most common neurodegenerative diseases that currently affect millions of persons within the United States population. While many clues about the mechanisms of these disorders have been uncovered, to date, the molecular mechanisms associated with the cause of these diseases are not completely understood. Furthermore, there are no available cures or preventive treatments for either disorder. Animal models of AD and PD, though not perfect, offer a means to gain knowledge of the basic biochemistry associated with these disorders and with drug efficacy. The field of proteomics which focuses on identifying the dynamic nature of the protein content expressed within a particular cell, tissue, or organism, has provided many insights into these disturbing disorders. Proteomic studies have revealed many pathways that are associated with disease pathogenesis and that may lead to the development of potential therapeutic targets. This review provides a discussion of key findings from AD and PD proteomics-based studies in various animal models of disease.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalAgeing Research Reviews
Volume8
Issue number1
DOIs
StatePublished - Jan 2009

Bibliographical note

Funding Information:
This work was supported in part by NIH grants to D.A.B. [AG-10836-AG-05119; AG-029839].

Keywords

  • Alzheimer's disease
  • Animal models
  • Parkinson's disease
  • Proteomics

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

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