Proteopathy: The next therapeutic frontier?

Lary C. Walker, Harry LeVine

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The abnormal conformation and assembly of proteins is a probable cause of many degenerative diseases of old age. These proteopathies include such clinically disparate neurological disorders as Alzheimer's disease, Parkinson's disease and Creutzfeldt-Jakob disease, as well as a variety of non-neurological maladies. The involvement of protein pathology in these diseases is well established and we are beginning to understand the process whereby proteins self-assemble and injure tissues; however, we remain largely in the dark regarding the fundamental origins of the proteopathies. Our present knowledge suggests three broad therapeutic approaches to abrogating the proteopathic cascade: reduce the production of the offending proteins, prevent their self-assembly, or promote their removal.

Original languageEnglish
Pages (from-to)782-787
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Volume3
Issue number5
StatePublished - May 1 2002

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid
  • Conformational disease
  • Creutzfeldt-Jakob disease
  • Dementia
  • Diabetes
  • Huntington's disease
  • Parkinson's disease
  • Prion
  • Proteopathy
  • Synuclein
  • Tau

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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