Psychosis and smoking cessation: Difficulties in quitting associated with sex and substance abuse

Ana González-Pinto; Susana Alberich; Sonia Ruiz de Azúa; Mónica Martínez-Cengotitabengoa; Miryam Fernández; Miguel Gutiérrez; Margarita Saenz; Ariadna Besga; Paloma Galdós; Jose de Leon

doi:10.1016/j.psychres.2011.08.005

Psychosis and smoking cessation: Difficulties in quitting associated with sex and substance abuse

Ana González-Pinto, Susana Alberich, Sonia Ruiz de Azúa, Mónica Martínez-Cengotitabengoa, Miryam Fernández, Miguel Gutiérrez, Margarita Saenz, Ariadna Besga, Paloma Galdós, Jose de Leon

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

No prospective studies of first psychotic episodes have explored sex differences in smoking cessation. The aim of this study was to determine the influence of sex and substance abuse on smoking cessation during an 8-year follow-up of patients after a first psychotic episode. Logistic regression modeling was used to identify factors associated with smoking cessation by sex. To examine for sex variable interactions, the following two methods were used: 1) for other clinical variables, mixed analyses were calculated; and 2) for use of other substances, logistic regression models were performed only in the substance users. At baseline, 79% of men and 84% of women were current smokers. Lower smoking cessation after 8. years was associated with female sex (odds ratio, OR = 0.30; 95% confidence intervals, CIs = 0.12-0.75) and treatment with typical antipsychotics (OR = 0.30, CIs = 0.10-0.93). In a logistic regression model of alcohol users, those who used alcohol continuously were less likely to stop smoking (adjusted OR = 0.22, CI = 0.05-1.0). Among patients who continued using cannabis, female sex was associated with significant lower smoking cessation (adjusted OR = 0.03, CI = 0.001-0.77). Sex may act as a moderator in smoking cessation after a first psychotic episode. Smoking cessation interventions in these patients should consider sex differences and comorbidity with alcohol and cannabis use.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Psychiatry Research
Volume	195
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2011.08.005
State	Published - Jan 30 2012

Bibliographical note

Funding Information:
Preparation of this article was supported by Health Research Funds from the Spanish Government ( PS09/02002, PI08/90439; PI08/90224; PI081213; PI081536; PI08/0873; EC07/90435; EC07/90666; CD08/00269; CM08/00213 ), CIBER Network (which is an initiative of ISCIII CB07/09/0024; P91A; P91E ), European Regional Development Funds (FEDER) , and by local grants ( GV20009111047; BIO09/EM/010; BIOEF09 and EHU08/54 ). Dr González Pinto is responsible for a specific collaborative agreement between the Spanish Government (SCIII) and the Basque Government to stabilize and intensify research in the National Health System (Boe no. 68 19, March 2010).). These institutions had no further role in the study design, data collection, analysis and interpretation, writing of the report, or in the decision to submit the paper for publication. No pharmaceutical company or commercial organization had any role in the writing of this paper for publication. In the last 12 months, Dr. de Leon was co-investigator with Genomas in a National Institutes of Health grant.

Keywords

Antipsychotic agents
Bipolar disorder
Female
Psychotic disorders
Schizophrenia
Tobacco

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2011.08.005

Cite this

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title = "Psychosis and smoking cessation: Difficulties in quitting associated with sex and substance abuse",

abstract = "No prospective studies of first psychotic episodes have explored sex differences in smoking cessation. The aim of this study was to determine the influence of sex and substance abuse on smoking cessation during an 8-year follow-up of patients after a first psychotic episode. Logistic regression modeling was used to identify factors associated with smoking cessation by sex. To examine for sex variable interactions, the following two methods were used: 1) for other clinical variables, mixed analyses were calculated; and 2) for use of other substances, logistic regression models were performed only in the substance users. At baseline, 79% of men and 84% of women were current smokers. Lower smoking cessation after 8. years was associated with female sex (odds ratio, OR = 0.30; 95% confidence intervals, CIs = 0.12-0.75) and treatment with typical antipsychotics (OR = 0.30, CIs = 0.10-0.93). In a logistic regression model of alcohol users, those who used alcohol continuously were less likely to stop smoking (adjusted OR = 0.22, CI = 0.05-1.0). Among patients who continued using cannabis, female sex was associated with significant lower smoking cessation (adjusted OR = 0.03, CI = 0.001-0.77). Sex may act as a moderator in smoking cessation after a first psychotic episode. Smoking cessation interventions in these patients should consider sex differences and comorbidity with alcohol and cannabis use.",

keywords = "Antipsychotic agents, Bipolar disorder, Female, Psychotic disorders, Schizophrenia, Tobacco",

author = "Ana Gonz{\'a}lez-Pinto and Susana Alberich and {Ruiz de Az{\'u}a}, Sonia and M{\'o}nica Mart{\'i}nez-Cengotitabengoa and Miryam Fern{\'a}ndez and Miguel Guti{\'e}rrez and Margarita Saenz and Ariadna Besga and Paloma Gald{\'o}s and {de Leon}, Jose",

note = "Funding Information: Preparation of this article was supported by Health Research Funds from the Spanish Government ( PS09/02002, PI08/90439; PI08/90224; PI081213; PI081536; PI08/0873; EC07/90435; EC07/90666; CD08/00269; CM08/00213 ), CIBER Network (which is an initiative of ISCIII CB07/09/0024; P91A; P91E ), European Regional Development Funds (FEDER) , and by local grants ( GV20009111047; BIO09/EM/010; BIOEF09 and EHU08/54 ). Dr Gonz{\'a}lez Pinto is responsible for a specific collaborative agreement between the Spanish Government (SCIII) and the Basque Government to stabilize and intensify research in the National Health System (Boe no. 68 19, March 2010).). These institutions had no further role in the study design, data collection, analysis and interpretation, writing of the report, or in the decision to submit the paper for publication. No pharmaceutical company or commercial organization had any role in the writing of this paper for publication. In the last 12 months, Dr. de Leon was co-investigator with Genomas in a National Institutes of Health grant. ",

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AU - González-Pinto, Ana

AU - Alberich, Susana

AU - Ruiz de Azúa, Sonia

AU - Martínez-Cengotitabengoa, Mónica

AU - Fernández, Miryam

AU - Gutiérrez, Miguel

AU - Saenz, Margarita

AU - Besga, Ariadna

AU - Galdós, Paloma

AU - de Leon, Jose

N1 - Funding Information: Preparation of this article was supported by Health Research Funds from the Spanish Government ( PS09/02002, PI08/90439; PI08/90224; PI081213; PI081536; PI08/0873; EC07/90435; EC07/90666; CD08/00269; CM08/00213 ), CIBER Network (which is an initiative of ISCIII CB07/09/0024; P91A; P91E ), European Regional Development Funds (FEDER) , and by local grants ( GV20009111047; BIO09/EM/010; BIOEF09 and EHU08/54 ). Dr González Pinto is responsible for a specific collaborative agreement between the Spanish Government (SCIII) and the Basque Government to stabilize and intensify research in the National Health System (Boe no. 68 19, March 2010).). These institutions had no further role in the study design, data collection, analysis and interpretation, writing of the report, or in the decision to submit the paper for publication. No pharmaceutical company or commercial organization had any role in the writing of this paper for publication. In the last 12 months, Dr. de Leon was co-investigator with Genomas in a National Institutes of Health grant.

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Psychosis and smoking cessation: Difficulties in quitting associated with sex and substance abuse

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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