Pulsatile protein release from monodisperse liquid-core microcapsules of controllable shell thickness

Yujie Xia, Daniel W. Pack

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: Pulsatile delivery of proteins, in which release occurs over a short time after a period of little or no release, is desirable for many applications. This paper investigates the effect of biodegradable polymer shell thickness on pulsatile protein release from biodegradable polymer microcapsules.

Methods: Using precision particle fabrication (PPF) technology, monodisperse microcapsules were fabricated encapsulating bovine serum albumin (BSA) in a liquid core surrounded by a drug-free poly(lactide-co-glycolide) (PLG) shell of uniform, controlled thickness from 14 to 19 μm.

Results: When using high molecular weight PLG (Mw 88 kDa), microparticles exhibited the desired core-shell structure with high BSA loading and encapsulation efficiency (55-65%). These particles exhibited very slow release of BSA for several weeks followed by rapid release of 80-90% of the encapsulated BSA within 7 days. Importantly, with increasing shell thickness the starting time of the pulsatile release could be controlled from 25 to 35 days.

Conclusions: Biodegradable polymer microcapsules with precisely controlled shell thickness provide pulsatile release with enhanced control of release profiles.

Original languageEnglish
Pages (from-to)3201-3210
Number of pages10
JournalPharmaceutical Research
Issue number11
StatePublished - Nov 2014

Bibliographical note

Publisher Copyright:
© 2014 Springer Science+Business Media New York.


  • bovine serum albumin
  • controlled release
  • monodisperse microcapsules
  • poly(lactide-co-glycolide)
  • pulsatile release

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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