Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.
|Number of pages||9|
|Journal||Medicinal Chemistry Research|
|State||Published - 2001|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics (all)
- Organic Chemistry