QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT1D/1B serotonin receptor ligands

T. Prisinzano; H. Law; A. Slassi; N. Maclean; L. Demchyshyn; R. A. Glennon

QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT_1D/1B serotonin receptor ligands

T. Prisinzano, H. Law, A. Slassi, N. Maclean, L. Demchyshyn, R. A. Glennon

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Human 5-HT_1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT_1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT_1D and h5-HT_1B receptor affinity.

Original language	English
Pages (from-to)	309-317
Number of pages	9
Journal	Medicinal Chemistry Research
Volume	10
Issue number	5
State	Published - 2001

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Organic Chemistry

Cite this

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abstract = "Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.",

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T1 - QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT1D/1B serotonin receptor ligands

AU - Prisinzano, T.

AU - Law, H.

AU - Slassi, A.

AU - Maclean, N.

AU - Demchyshyn, L.

AU - Glennon, R. A.

PY - 2001

Y1 - 2001

N2 - Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.

AB - Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.

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M3 - Article

AN - SCOPUS:0035041727

SN - 1054-2523

VL - 10

SP - 309

EP - 317

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 5

ER -

QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT_1D/1B serotonin receptor ligands

Abstract

ASJC Scopus subject areas

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