Quality of Life After Removal of Left Ventricular Assist Device for Myocardial Recovery

Robert S. George, Magdi H. Yacoub, Christopher T. Bowles, Mandy Hipkin, Paula Rogers, Claire Hallas, Nicholas R. Banner, Gilles Dreyfus, Asghar Khaghani, Emma J. Birks

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Background: Longer term quality of life (QOL) outcome in patients who have had a left ventricular assist device (LVAD) explanted due to myocardial recovery (bridge to recovery, BTR) remains uncertain. This study evaluates the QOL of those patients and compares them to bridge-to-transplant (BTT) and transplanted (Tx) patients. Methods: Anonymized QOL Short Form (SF)-36 questionnaires were sent to a total of 72 patients, including: 14 BTR patients (3.6 ± 1.9 years since LVAD removal); 29 BTT patients (3.3 ± 2.3 years since transplantation); and 29 Tx patients (3.8 ± 0.6 years since transplantation). Results: Questionnaires were returned by 78.6%, 79.3% and 56.7% of patients from the BTR, BTT and Tx groups, respectively. In all but two of the domains of the SF-36 questionnaire, scores were significantly better in the BTR group compared with the BTT and Tx groups. Analysis of the two main dimensions and the total SF-36 score between the three groups showed that: (i) physical health dimension tended to be better in BTR (71.9 ± 21) vs BTT (64.5 ± 23.2) and Tx (41.4 ± 48) groups (p = not statistically significant [NS]); (ii) mental health dimension was better in both BTR (78 ± 16.1) and BTT (71.4 ± 21.1) groups compared with the Tx group (39.4 ± 44, p < 0.05); and (iii) total SF-36 score was significantly higher in the BTR and BTT groups compared with the Tx group (76.8 ± 17.6 and 69 ± 21.1 vs 41.4 ± 48, p = NS). Conclusions: BTR patients appear to have better QOL than both BTT and Tx patients. In addition, BTT patients seem to have a better QOL compared with Tx patients, suggesting that placement of ventricular assist devices could improve the physiologic outcome for transplanted patients.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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