Quantitative assessment of lipoprotein metabolism by positron emission tomography with an 18F-containing residualizing label

Alan Daugherty; Michael R. Kilbourn; Carmen S. Dence; Burton E. Sobel; Suzanne R. Thorpe

doi:10.1016/0883-2897(92)90127-K

Quantitative assessment of lipoprotein metabolism by positron emission tomography with an ¹⁸F-containing residualizing label

Alan Daugherty, Michael R. Kilbourn, Carmen S. Dence, Burton E. Sobel, Suzanne R. Thorpe

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Residualizing labels for proteins are designed to remain entrapped within cells following uptake and degradation of the carrier protein. In the present work we report the synthesis of a novel residualizing label, N-lactitol-S-([¹⁸F]fluorophenacyl)-cysteamine ([¹⁸F]LCSH, and its use for quantifying the accumulation of low density lipoprotein in tissues in vivo by positron emission tomography (PET). The retention of degradation products in tissues from lipoprotein or from other rapidly catabolized protein pharmaceuticals tagged with [¹⁸F]LCSH reduces leakage of tracer into the plasma compartment. Thus, residualizing labels provide a valuable tool for enhancing signal-to-noise ratios, even during the relatively short interval of PET studies.

Original language	English
Pages (from-to)	411-413,415-416
Journal	International Journal of Radiation Applications and Instrumentation.
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0883-2897(92)90127-K
State	Published - Apr 1992

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/0883-2897(92)90127-K

Cite this

@article{c6a92e81a52e4387a039420a56274d25,

title = "Quantitative assessment of lipoprotein metabolism by positron emission tomography with an 18F-containing residualizing label",

abstract = "Residualizing labels for proteins are designed to remain entrapped within cells following uptake and degradation of the carrier protein. In the present work we report the synthesis of a novel residualizing label, N-lactitol-S-([18F]fluorophenacyl)-cysteamine ([18F]LCSH, and its use for quantifying the accumulation of low density lipoprotein in tissues in vivo by positron emission tomography (PET). The retention of degradation products in tissues from lipoprotein or from other rapidly catabolized protein pharmaceuticals tagged with [18F]LCSH reduces leakage of tracer into the plasma compartment. Thus, residualizing labels provide a valuable tool for enhancing signal-to-noise ratios, even during the relatively short interval of PET studies.",

author = "Alan Daugherty and Kilbourn, {Michael R.} and Dence, {Carmen S.} and Sobel, {Burton E.} and Thorpe, {Suzanne R.}",

year = "1992",

month = apr,

doi = "10.1016/0883-2897(92)90127-K",

language = "English",

volume = "19",

pages = "411--413,415--416",

number = "3",

}

Quantitative assessment of lipoprotein metabolism by positron emission tomography with an ¹⁸F-containing residualizing label. / Daugherty, Alan; Kilbourn, Michael R.; Dence, Carmen S. et al.
In: International Journal of Radiation Applications and Instrumentation., Vol. 19, No. 3, 04.1992, p. 411-413,415-416.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantitative assessment of lipoprotein metabolism by positron emission tomography with an 18F-containing residualizing label

AU - Daugherty, Alan

AU - Kilbourn, Michael R.

AU - Dence, Carmen S.

AU - Sobel, Burton E.

AU - Thorpe, Suzanne R.

PY - 1992/4

Y1 - 1992/4

N2 - Residualizing labels for proteins are designed to remain entrapped within cells following uptake and degradation of the carrier protein. In the present work we report the synthesis of a novel residualizing label, N-lactitol-S-([18F]fluorophenacyl)-cysteamine ([18F]LCSH, and its use for quantifying the accumulation of low density lipoprotein in tissues in vivo by positron emission tomography (PET). The retention of degradation products in tissues from lipoprotein or from other rapidly catabolized protein pharmaceuticals tagged with [18F]LCSH reduces leakage of tracer into the plasma compartment. Thus, residualizing labels provide a valuable tool for enhancing signal-to-noise ratios, even during the relatively short interval of PET studies.

AB - Residualizing labels for proteins are designed to remain entrapped within cells following uptake and degradation of the carrier protein. In the present work we report the synthesis of a novel residualizing label, N-lactitol-S-([18F]fluorophenacyl)-cysteamine ([18F]LCSH, and its use for quantifying the accumulation of low density lipoprotein in tissues in vivo by positron emission tomography (PET). The retention of degradation products in tissues from lipoprotein or from other rapidly catabolized protein pharmaceuticals tagged with [18F]LCSH reduces leakage of tracer into the plasma compartment. Thus, residualizing labels provide a valuable tool for enhancing signal-to-noise ratios, even during the relatively short interval of PET studies.

UR - http://www.scopus.com/inward/record.url?scp=44049121734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44049121734&partnerID=8YFLogxK

U2 - 10.1016/0883-2897(92)90127-K

DO - 10.1016/0883-2897(92)90127-K

M3 - Article

C2 - 1629030

AN - SCOPUS:44049121734

SN - 0883-2897

VL - 19

SP - 411-413,415-416

JO - International Journal of Radiation Applications and Instrumentation.

JF - International Journal of Radiation Applications and Instrumentation.

IS - 3

ER -