Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

doi:10.1007/s00261-022-03654-7

Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: To determine if quantitative MRI techniques can be helpful to evaluate chronic pancreatitis (CP) in a setting of multi-institutional study. Methods: This study included a subgroup of participants (n = 101) enrolled in the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) study (NCT03099850) from February 2019 to May 2021. MRI was performed on 1.5 T using Siemens and GE scanners at seven clinical centers across the USA. Quantitative MRI parameters of the pancreas included T1 relaxation time, extracellular volume (ECV) fraction, apparent diffusion coefficient (ADC), and fat signal fraction. We report the diagnostic performance and mean values within the control (n = 50) and CP (n = 51) groups. The T1, ECV and fat signal fraction were combined to generate the quantitative MRI score (Q-MRI). Results: There was significantly higher T1 relaxation time; mean 669 ms (± 171) vs. 593 ms (± 82) (p = 0.006), ECV fraction; 40.2% (± 14.7) vs. 30.3% (± 11.9) (p < 0.001), and pancreatic fat signal fraction; 12.2% (± 5.5) vs. 8.2% (± 4.4) (p < 0.001) in the CP group compared to controls. The ADC was similar between groups (p = 0.45). The AUCs for the T1, ECV, and pancreatic fat signal fraction were 0.62, 0.72, and 0.73, respectively. The composite Q-MRI score improved the diagnostic performance (cross-validated AUC: 0.76). Conclusion: Quantitative MR parameters evaluating the pancreatic parenchyma (T1, ECV fraction, and fat signal fraction) are helpful in the diagnosis of CP. A Q-MRI score that combines these three MR parameters improves diagnostic performance. Further studies are warranted with larger study populations including patients with acute and recurrent acute pancreatitis and longitudinal follow-ups. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	3792-3805
Number of pages	14
Journal	Abdominal Radiology
Volume	47
Issue number	11
DOIs	https://doi.org/10.1007/s00261-022-03654-7
State	Published - Nov 2022

Bibliographical note

Funding Information:
Research reported in this publication was supported by National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award numbers related to: the MINIMAP study (R01DK116963) and The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) under award numbers: U01DK108328 (CDMC), U01DK108323 (IU), U01DK108306 (UPMC), U01DK108327 (OSU), U01DK108327 (CSMC), DKP3041301 (UCLA), U01DK108300 (Stanford) and U01DK108288 (Mayo). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
We acknowledge Ely Felker, MD, Shreyas Vasanawala, MD and April Fase, RN for their participation in this study. We acknowledge support of ChiRhoClin Inc. (Burtonsville, MD, USA) for supplying the Secretin (ChiRhoStim).

Funding Information:
We present the results of a multi-institutional pilot study, Magnetic Resonance Imaging as a Non-Invasive Method for the Assessment of Pancreatic Fibrosis (MINIMAP) [], funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as an ancillary study within the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) [, ]. Our aim with the MINIMAP study was to explore the potential of quantitative parenchymal MRI features serving as a non-invasive imaging biomarker for CP [].

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Chronic pancreatitis
Extracellular volume fraction
Fat signal fraction
T1 mapping

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Gastroenterology
Urology

Access to Document

10.1007/s00261-022-03654-7

Cite this

@article{a30661035fd44986a329d498365aaec4,

title = "Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)",

abstract = "Purpose: To determine if quantitative MRI techniques can be helpful to evaluate chronic pancreatitis (CP) in a setting of multi-institutional study. Methods: This study included a subgroup of participants (n = 101) enrolled in the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) study (NCT03099850) from February 2019 to May 2021. MRI was performed on 1.5 T using Siemens and GE scanners at seven clinical centers across the USA. Quantitative MRI parameters of the pancreas included T1 relaxation time, extracellular volume (ECV) fraction, apparent diffusion coefficient (ADC), and fat signal fraction. We report the diagnostic performance and mean values within the control (n = 50) and CP (n = 51) groups. The T1, ECV and fat signal fraction were combined to generate the quantitative MRI score (Q-MRI). Results: There was significantly higher T1 relaxation time; mean 669 ms (± 171) vs. 593 ms (± 82) (p = 0.006), ECV fraction; 40.2% (± 14.7) vs. 30.3% (± 11.9) (p < 0.001), and pancreatic fat signal fraction; 12.2% (± 5.5) vs. 8.2% (± 4.4) (p < 0.001) in the CP group compared to controls. The ADC was similar between groups (p = 0.45). The AUCs for the T1, ECV, and pancreatic fat signal fraction were 0.62, 0.72, and 0.73, respectively. The composite Q-MRI score improved the diagnostic performance (cross-validated AUC: 0.76). Conclusion: Quantitative MR parameters evaluating the pancreatic parenchyma (T1, ECV fraction, and fat signal fraction) are helpful in the diagnosis of CP. A Q-MRI score that combines these three MR parameters improves diagnostic performance. Further studies are warranted with larger study populations including patients with acute and recurrent acute pancreatitis and longitudinal follow-ups. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Chronic pancreatitis, Extracellular volume fraction, Fat signal fraction, T1 mapping",

author = "Temel Tirkes and Dhiraj Yadav and Conwell, {Darwin L.} and Territo, {Paul R.} and Xuandong Zhao and Persohn, {Scott A.} and Dasyam, {Anil K.} and Shah, {Zarine K.} and Venkatesh, {Sudhakar K.} and Naoki Takahashi and Ashley Wachsman and Liang Li and Yan Li and Pandol, {Stephen J.} and Park, {Walter G.} and Vege, {Santhi S.} and Hart, {Phil A.} and Mark Topazian and Andersen, {Dana K.} and Fogel, {Evan L.}",

note = "Funding Information: Research reported in this publication was supported by National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award numbers related to: the MINIMAP study (R01DK116963) and The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) under award numbers: U01DK108328 (CDMC), U01DK108323 (IU), U01DK108306 (UPMC), U01DK108327 (OSU), U01DK108327 (CSMC), DKP3041301 (UCLA), U01DK108300 (Stanford) and U01DK108288 (Mayo). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: We acknowledge Ely Felker, MD, Shreyas Vasanawala, MD and April Fase, RN for their participation in this study. We acknowledge support of ChiRhoClin Inc. (Burtonsville, MD, USA) for supplying the Secretin (ChiRhoStim). Funding Information: We present the results of a multi-institutional pilot study, Magnetic Resonance Imaging as a Non-Invasive Method for the Assessment of Pancreatic Fibrosis (MINIMAP) [], funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as an ancillary study within the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) [, ]. Our aim with the MINIMAP study was to explore the potential of quantitative parenchymal MRI features serving as a non-invasive imaging biomarker for CP []. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = nov,

doi = "10.1007/s00261-022-03654-7",

language = "English",

volume = "47",

pages = "3792--3805",

journal = "Abdominal Radiology",

issn = "2366-004X",

publisher = "Springer New York",

number = "11",

}

TY - JOUR

T1 - Quantitative MRI of chronic pancreatitis

T2 - results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

AU - Tirkes, Temel

AU - Yadav, Dhiraj

AU - Conwell, Darwin L.

AU - Territo, Paul R.

AU - Zhao, Xuandong

AU - Persohn, Scott A.

AU - Dasyam, Anil K.

AU - Shah, Zarine K.

AU - Venkatesh, Sudhakar K.

AU - Takahashi, Naoki

AU - Wachsman, Ashley

AU - Li, Liang

AU - Li, Yan

AU - Pandol, Stephen J.

AU - Park, Walter G.

AU - Vege, Santhi S.

AU - Hart, Phil A.

AU - Topazian, Mark

AU - Andersen, Dana K.

AU - Fogel, Evan L.

N1 - Funding Information: Research reported in this publication was supported by National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award numbers related to: the MINIMAP study (R01DK116963) and The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) under award numbers: U01DK108328 (CDMC), U01DK108323 (IU), U01DK108306 (UPMC), U01DK108327 (OSU), U01DK108327 (CSMC), DKP3041301 (UCLA), U01DK108300 (Stanford) and U01DK108288 (Mayo). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: We acknowledge Ely Felker, MD, Shreyas Vasanawala, MD and April Fase, RN for their participation in this study. We acknowledge support of ChiRhoClin Inc. (Burtonsville, MD, USA) for supplying the Secretin (ChiRhoStim). Funding Information: We present the results of a multi-institutional pilot study, Magnetic Resonance Imaging as a Non-Invasive Method for the Assessment of Pancreatic Fibrosis (MINIMAP) [], funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as an ancillary study within the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) [, ]. Our aim with the MINIMAP study was to explore the potential of quantitative parenchymal MRI features serving as a non-invasive imaging biomarker for CP []. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022/11

Y1 - 2022/11

N2 - Purpose: To determine if quantitative MRI techniques can be helpful to evaluate chronic pancreatitis (CP) in a setting of multi-institutional study. Methods: This study included a subgroup of participants (n = 101) enrolled in the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) study (NCT03099850) from February 2019 to May 2021. MRI was performed on 1.5 T using Siemens and GE scanners at seven clinical centers across the USA. Quantitative MRI parameters of the pancreas included T1 relaxation time, extracellular volume (ECV) fraction, apparent diffusion coefficient (ADC), and fat signal fraction. We report the diagnostic performance and mean values within the control (n = 50) and CP (n = 51) groups. The T1, ECV and fat signal fraction were combined to generate the quantitative MRI score (Q-MRI). Results: There was significantly higher T1 relaxation time; mean 669 ms (± 171) vs. 593 ms (± 82) (p = 0.006), ECV fraction; 40.2% (± 14.7) vs. 30.3% (± 11.9) (p < 0.001), and pancreatic fat signal fraction; 12.2% (± 5.5) vs. 8.2% (± 4.4) (p < 0.001) in the CP group compared to controls. The ADC was similar between groups (p = 0.45). The AUCs for the T1, ECV, and pancreatic fat signal fraction were 0.62, 0.72, and 0.73, respectively. The composite Q-MRI score improved the diagnostic performance (cross-validated AUC: 0.76). Conclusion: Quantitative MR parameters evaluating the pancreatic parenchyma (T1, ECV fraction, and fat signal fraction) are helpful in the diagnosis of CP. A Q-MRI score that combines these three MR parameters improves diagnostic performance. Further studies are warranted with larger study populations including patients with acute and recurrent acute pancreatitis and longitudinal follow-ups. Graphical abstract: [Figure not available: see fulltext.]

AB - Purpose: To determine if quantitative MRI techniques can be helpful to evaluate chronic pancreatitis (CP) in a setting of multi-institutional study. Methods: This study included a subgroup of participants (n = 101) enrolled in the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) study (NCT03099850) from February 2019 to May 2021. MRI was performed on 1.5 T using Siemens and GE scanners at seven clinical centers across the USA. Quantitative MRI parameters of the pancreas included T1 relaxation time, extracellular volume (ECV) fraction, apparent diffusion coefficient (ADC), and fat signal fraction. We report the diagnostic performance and mean values within the control (n = 50) and CP (n = 51) groups. The T1, ECV and fat signal fraction were combined to generate the quantitative MRI score (Q-MRI). Results: There was significantly higher T1 relaxation time; mean 669 ms (± 171) vs. 593 ms (± 82) (p = 0.006), ECV fraction; 40.2% (± 14.7) vs. 30.3% (± 11.9) (p < 0.001), and pancreatic fat signal fraction; 12.2% (± 5.5) vs. 8.2% (± 4.4) (p < 0.001) in the CP group compared to controls. The ADC was similar between groups (p = 0.45). The AUCs for the T1, ECV, and pancreatic fat signal fraction were 0.62, 0.72, and 0.73, respectively. The composite Q-MRI score improved the diagnostic performance (cross-validated AUC: 0.76). Conclusion: Quantitative MR parameters evaluating the pancreatic parenchyma (T1, ECV fraction, and fat signal fraction) are helpful in the diagnosis of CP. A Q-MRI score that combines these three MR parameters improves diagnostic performance. Further studies are warranted with larger study populations including patients with acute and recurrent acute pancreatitis and longitudinal follow-ups. Graphical abstract: [Figure not available: see fulltext.]

KW - Chronic pancreatitis

KW - Extracellular volume fraction

KW - Fat signal fraction

KW - T1 mapping

UR - http://www.scopus.com/inward/record.url?scp=85137303708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137303708&partnerID=8YFLogxK

U2 - 10.1007/s00261-022-03654-7

DO - 10.1007/s00261-022-03654-7

M3 - Article

C2 - 36038644

AN - SCOPUS:85137303708

SN - 2366-004X

VL - 47

SP - 3792

EP - 3805

JO - Abdominal Radiology

JF - Abdominal Radiology

IS - 11

ER -

Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this