Quantitative neuropathological assessment to investigate cerebral multi-morbidity

Johannes Attems, Janna H. Neltner, Peter T. Nelson

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The aging brain is characterized by the simultaneous presence of multiple pathologies, and the prevalence of cerebral multi-morbidity increases with age. To understand the impact of each subtype of pathology and the combined effects of cerebral multi-morbidity on clinical signs and symptoms, large clinico-pathological correlative studies have been performed. However, such studies are often based on semi-quantitative assessment of neuropathological hallmark lesions. Here, we discuss some of the new methods for high-throughput quantitative neuropathological assessment. These methods combine increased quantitative rigor with the added technical capacity of computers and networked analyses. There are abundant new opportunities - with specific techniques that include slide scanners, automated microscopes, and tissue microarrays - and also potential pitfalls. We conclude that quantitative and digital neuropathologic approaches will be key resources to further elucidate cerebral multi-morbidity in the aged brain and also hold the potential for changing routine neuropathologic diagnoses.

Original languageEnglish
Article number85
JournalAlzheimer's Research and Therapy
Volume6
Issue number9
DOIs
StatePublished - Nov 28 2014

Bibliographical note

Publisher Copyright:
© 2014 Attems et al.; licensee BioMed Central Ltd.

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Fingerprint

Dive into the research topics of 'Quantitative neuropathological assessment to investigate cerebral multi-morbidity'. Together they form a unique fingerprint.

Cite this