Quantitative Sodium MR Imaging and Sodium Bioscales for the Management of Brain Tumors

Keith R. Thulborn, Aiming Lu, Ian C. Atkinson, Fred Damen, John L. Villano

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Treatment of high-grade primary brain tumors is based on experience from multicenter trials. However, the prognosis has changed little in 3 decades. This suggests that there is a fundamental oversight in treatment. This article provides an imaging perspective of how regional responses of primary brain tumors may be examined to guide a flexible treatment plan. Sodium imaging provides a measurement of cell density that can be used to measure regional cell kill. Such a bioscales of regionally and temporally sensitive biologic-based parameters may be helpful to guide tumor treatment. These suggestions are speculative and still being examined, but are presented to challenge the medical community to be receptive to changes in the standard of care when that standard continues to fail.

Original languageEnglish
Pages (from-to)615-624
Number of pages10
JournalNeuroimaging Clinics of North America
Issue number4
StatePublished - Nov 2009


  • Bioscales
  • Brain tumor
  • Imaging treatment response
  • Sodium MR imaging
  • Tissue viability
  • Treatment protocols

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


Dive into the research topics of 'Quantitative Sodium MR Imaging and Sodium Bioscales for the Management of Brain Tumors'. Together they form a unique fingerprint.

Cite this