TY - JOUR
T1 - Quercitrin protects skin from UVB-induced oxidative damage
AU - Yin, Yuanqin
AU - Li, Wenqi
AU - Son, Young Ok
AU - Sun, Lijuan
AU - Lu, Jian
AU - Kim, Donghern
AU - Wang, Xin
AU - Yao, Hua
AU - Wang, Lei
AU - Pratheeshkumar, Poyil
AU - Hitron, Andrew J.
AU - Luo, Jia
AU - Gao, Ning
AU - Shi, Xianglin
AU - Zhang, Zhuo
N1 - Funding Information:
This study was supported by NIH 1R21ES019249 to Dr. Z. Zhang and Dr. X. Shi.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.
AB - Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.
KW - Antioxidant
KW - Apoptosis
KW - Inflammation
KW - Oxidative damage
KW - Quercitrin
KW - Ultraviolet B
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U2 - 10.1016/j.taap.2013.03.015
DO - 10.1016/j.taap.2013.03.015
M3 - Article
C2 - 23545178
AN - SCOPUS:84876372751
SN - 0041-008X
VL - 269
SP - 89
EP - 99
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 2
ER -
