Quinolinic acid, an endogenous metabolite with neurotoxic properties, alters the physical state of membrane proteins in human erythrocytes

Bennett T. Farmer, D. Allan Butterfield

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Quinolinic acid (2, 3-pyridinedicarboxylic acid), an endogenous, tryptophan metabolite, is neurotoxic when injected into rat striatum (1). To begin to investigate the molecular interactions of quinolinic acid with membranes, electron spin resonance studies of the effects of this neurotoxin on the physical state of lipids, proteins, and cell-surface sialic acid in human erythrocyte ghosts have been performed. Quinolinic acid induced a highly significant alteration in the physical state of membrane proteins (P<0.01) while that of sialic acid and membrane lipids was unaffected. These results are similar to those induced by ibotenic acid, an exogenous neurotoxin, and are discussed with reference to possible molecular characteristics of the interaction of these neurotoxins with membrane proteins.

Original languageEnglish
Pages (from-to)501-509
Number of pages9
JournalLife Sciences
Volume35
Issue number5
DOIs
StatePublished - Jul 30 1984

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Institutes of Health (NS-13791; AG-O0084; AG-02759).

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)

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