Quorum sensing by the Lyme disease spirochete

Brian Stevenson, Kate Von Lackum, Rachel L. Wattier, Jason D. McAlister, Jennifer C. Miller, Kelly Babb

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The Lyme disease spirochete, Borrelia burgdorferi, utilizes a LuxS/autoinducer-2-dependent quorum sensing mechanism to control a specific subset of bacterial proteins. It is hypothesized that this system facilitates transmission of B. burgdorferi from feeding ticks into warm-blooded hosts.

Original languageEnglish
Pages (from-to)991-997
Number of pages7
JournalMicrobes and Infection
Issue number11
StatePublished - Sep 2003

Bibliographical note

Funding Information:
Research in our laboratory is funded by U.S. National Institutes of Health grants R01–AI44254, R01–AI53101, and 5T32–AI49795. We thank Natalie Mickelsen for technical assistance and John Carmen for comments on this manuscript.


  • Autoinducer
  • Borrelia burgdorferi
  • LuxS
  • Relapsing fever
  • Tick

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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