Race- and sex-associated differences in rate-adjusted QT, QTpeak, ST elevation and other regional measures of repolarization: The Atherosclerosis Risk in Communities (ARIC) Study

Pentti M. Rautaharju, Zhu Ming Zhang, Wesley K. Haisty, Richard E. Gregg, James Warren, Milan B. Horaĉek, Anna M. Kucharska-Newton, Wayne Rosamond, Elsayed Z. Soliman

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background Data are limited about race-and sex-associated differences in prognostically important ECG measures of regional repolarization. Methods and results The normal reference group from the Atherosclerosis Risk in Communities (ARIC) study included 8,676 white and African-American men and women aged 40-65 years. Exclusion criteria included cardiovascular disease, hypertension, diabetes and major ECG abnormalities. Notable sex differences (p < 0.001) were observed in the upper 98% limits for rate-adjusted QTend (QTea) which was 435 ms in white and African-American men and 445 ms in white and African-American women, and for left ventricular epicardial repolarization time (RTepi) which was 345 ms in white and African-American men and 465 ms in white and African-American women. These sex differences reflect earlier onset and end of repolarization in men than in women. Upper normal limits for STJ amplitude in V2-V3 were 100 μV in white and African-American women, 150 μV in white men and 200 μV in African-American men (p < 0.001 for sex differences), and for other chest leads, aVL and aVF 50 μV in white women, 100 μV in African-American women, 100 μV in white men and 150 μV in African-American men (p < 0.001 for sex and race differences). Conclusions Shorter QTea and RTepi in men than in women reflect earlier onset and end of repolarization in men. STJ amplitudes in African-American men were higher than in other subgroups by race and sex. These sex and race differences need to be considered in clinical and epidemiological applications of normal standards.

Original languageEnglish
Pages (from-to)342-350
Number of pages9
JournalJournal of Electrocardiology
Volume47
Issue number3
DOIs
StatePublished - 2014

Bibliographical note

Funding Information:
This work was supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ).

Keywords

  • Electrocardiogram
  • QT
  • Race
  • ST-T wave
  • Sex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Race- and sex-associated differences in rate-adjusted QT, QTpeak, ST elevation and other regional measures of repolarization: The Atherosclerosis Risk in Communities (ARIC) Study'. Together they form a unique fingerprint.

Cite this