Radiation therapy as part of local control of metastatic neuroblastoma: the St Jude Children's Research Hospital experience

Jared R. Robbins, Matthew J. Krasin, Atmaram S. Pai Panandiker, Amy Watkins, Jianrong Wu, Victor M. Santana, Wayne L. Furman, Andrew M. Davidoff, Lisa M. McGregor

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose: The purpose of the study was to compare outcomes of pediatric patients with high-risk metastatic neuroblastoma who received radiotherapy (RT) with those of patients who did not. Patients and methods: We reviewed the records of 63 patients with newly diagnosed metastatic neuroblastoma treated at our institution (1989-2001) to investigate their characteristics at presentation, dose and field of RT, treatment response, and failure patterns. Results: Seventeen patients received RT, and 46 did not. In the RT group, a greater percentage of patients had residual disease before consolidation than did those in the no-RT group (88.2% vs 69.6%, P = .008). Gross total resection was achieved less often in the RT group (65% vs 89%, P = .055), but the 5-year cumulative incidences of local failure were similar (35.3% ± 12.4% vs 32.6% ± 7.1%). Although there was no difference in 5-year event-free survival, overall survival was better in the no-RT group (47.8% ± 7.2% vs 23.5% ± 9.2%, P = .026). Conclusion: The addition of RT to the therapy of a group of patients with more residual locoregional disease appeared to improve the local failure rate to approximately that of patients with less residual disease. Radiotherapy may provide even greater benefit to those with less residual disease before consolidation.

Original languageEnglish
Pages (from-to)678-686
Number of pages9
JournalJournal of Pediatric Surgery
Issue number4
StatePublished - Apr 2010

Bibliographical note

Funding Information:
This work was supported by Childhood Cancer Solid Tumor Program Project Grant CA-23099 and Cancer Center Support Grant CA-21765 from the National Cancer Institute and by the American Lebanese Syrian Associated Charities. Neither of these funding sources were involved in the design, conduct, or reporting of this study. We thank Angela McArthur and Brenda Clark for assistance with manuscript preparation.


  • Neoplasm recurrence, local
  • Neuroblastoma
  • Radiotherapy
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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