Abstract
The present study adopted a randomized controlled trial design and examined the effect of a physical activity behavioral intervention on cognitive and walking performance among persons with MS who have mild or moderate disability status. A total of 82 MS patients were randomly allocated into intervention or wait-list control conditions. The intervention condition received a theory-based program for increasing physical activity behavior that was delivered via the Internet, and one-on-one video chat sessions with a behavior-change coach. Participants completed self-report measures of physical activity and disability status, and underwent the oral Symbol Digit Modalities Test (SDMT) and 6-minute walk (6MW) test before and after the 6-month period. Analysis using mixed-model ANOVA indicated a significant time x condition x disability group interaction on SDMT scores (p = 0.02, partial-η2 = 0.08), such that persons with mild disability in the intervention condition demonstrated a clinically meaningful improvement in SDMT scores (∼6 point change). There was a further significant time x condition interaction on 6MW distance (p = 0.02, partial-η2 = 0.07), such that those in the intervention condition demonstrated an increase in 6MW distance relative to those in the control group. The current study supports physical activity as a promising tool for managing cognitive impairment and impaired walking performance in persons with MS, and suggests that physical activity might have specific effects on cognition and non-specific effects on walking performance in this population.
Original language | English |
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Pages (from-to) | 363-372 |
Number of pages | 10 |
Journal | Journal of Neurology |
Volume | 261 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2014 |
Bibliographical note
Funding Information:This study was funded by a grant from the National Multiple Sclerosis Society, Grant Number PP1695, awarded to the last author.
Keywords
- Cognition
- Multiple sclerosis
- Physical activity
- Walking
ASJC Scopus subject areas
- Neurology
- Clinical Neurology