Randomized study of single-dose, three-day, and seven-day treatment of cystitis in women

Richard N. Greenberg, Patrick M. Reilly, Kevin L. Luppen, William J. Weinandt, Lisa L. Ellington, Margaret R. Bollinger

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Weevaluated the following five treatment regimens for acute cystitis in nonpregnant women: cefadroxil, 1, 000 mg single-dose; cefadroxil, 500 mg twice a day for three days; cefadroxil, 500 mg twice a day for seven days; trimethoprim-sulfamethoxazole (TMP-SMZ), 320–1, 600 mg single-dose, and TMP-SMZ, 160–800 mg twice a day for three days. At four weeks after the end of treatment, 25%, 58%, 70%, 65%, and 88% of patients, respectively, remained cured of infection. The results indicated that three-day treatment (1) might improve cure rates (over single-dose), (2) would reduce incidence of relapse (vs. single-dose), and (3) may be as curative as seven-day treatment. The results of the antibody-coated bacteria test did not predict treatment failure or relapse.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalJournal of Infectious Diseases
Issue number2
StatePublished - Feb 1986

Bibliographical note

Funding Information:
Received for publication 21 May 1985, and in revised form 27 August 1985. This study was funded in part by a grant from Bristol Research Laboratories. We thank the nurse practitioners at St. Louis City Hospital; the following emergency room and clinic physicians for patient referrals: Drs. Antworth, Cometa, Devera, Hochreiter, Kulkamthorn, Lamb, Malano, Marino, Ronnau, Schlitchtig, Smith, Silver, and Punjabi; and Sue Stevens and Anita Boone for their secretarial assistance. The laboratory of Dr. Richard A. Wilson, Director of the Escherichia coli Reference Center, Department of Veterinary Science, Pennsylvania State University, kindly performed E. coli serotyping. Please address requests for reprints to Dr. Richard Greenberg, Divisionof Infectious Diseases, Department of Medicine, St. Louis University School of Medicine, 1402 South Grand Avenue, St. Louis, Missouri 63104.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


Dive into the research topics of 'Randomized study of single-dose, three-day, and seven-day treatment of cystitis in women'. Together they form a unique fingerprint.

Cite this