Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022

Tricia A. Aden; Patricia Blevins; Shannon Whitman York; Stacy Rager; Devika Balachandran; Christina L. Hutson; David Lowe; Chris N. Mangal; Tyler Wolford; Audrey Matheny; Whitni Davidson; Kimberly Wilkins; Rachael Cook; Rebecca M. Roulo; Michael K. White; La Shondra Berman; Janna’ Murray; John Laurance; Drew Francis; Nicole M. Green; Ricardo A. Berumen; Anthony Gonzalez; Stacy Evans; Meghan Hudziec; Diane Noel; Michael Adjei; Gregory Hovan; Phil Lee; Lisa Tate; Remedios B. Gose; Robert Voermans; Jennifer Crew; Phillip R. Adam; Danielle Haydel; Salimatu Lukula; Nick Matluk; Sandip Shah; Joshua Featherston; Daphne Ware; Denise Pettit; Emily McCutchen; Edward Acheampong; Erin Buttery; Andrew Gorzalski; Michael Perry; Randal Fowler; Robert B. Lee; Robert Nickla; Richard Huard; Amanda Moore; Katie Jones; Renee Johnson; Erin Swaney; Juan Jaramillo; Cynthia Reinoso Webb; Brandon Guin; Janine Yost; Annette Atkinson; Latoya Griffin-Thomas; Jessica Chenette; Jessica Gant; Alana Sterkel; Harjinder K. Ghuman; James Lute; Sandra C. Smole; Vaneet Arora; Courtney K. Demontigny; Meilan Bielby; Evelyn Geeter; Kimberly A.M. Newman; Mark Glazier; Whitney Lutkemeier; Megan Nelson; Raymond Martinez; Jasmine Chaitram; Margaret A. Honein; Julie M. Villanueva

doi:10.15585/mmwr.mm7128e1

Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022

Tricia A. Aden
, Patricia Blevins
, Shannon Whitman York
, Stacy Rager
, Devika Balachandran
, Christina L. Hutson
, David Lowe
, Chris N. Mangal
, Tyler Wolford
, Audrey Matheny
, Whitni Davidson
, Kimberly Wilkins
, Rachael Cook
, Rebecca M. Roulo
, Michael K. White
, La Shondra Berman
, Janna’ Murray
, John Laurance
, Drew Francis
, Nicole M. Green

Ricardo A. Berumen, Anthony Gonzalez, Stacy Evans, Meghan Hudziec, Diane Noel, Michael Adjei, Gregory Hovan, Phil Lee, Lisa Tate, Remedios B. Gose, Robert Voermans, Jennifer Crew, Phillip R. Adam, Danielle Haydel, Salimatu Lukula, Nick Matluk, Sandip Shah, Joshua Featherston, Daphne Ware, Denise Pettit, Emily McCutchen, Edward Acheampong, Erin Buttery, Andrew Gorzalski, Michael Perry, Randal Fowler, Robert B. Lee, Robert Nickla, Richard Huard, Amanda Moore, Katie Jones, Renee Johnson, Erin Swaney, Juan Jaramillo, Cynthia Reinoso Webb, Brandon Guin, Janine Yost, Annette Atkinson, Latoya Griffin-Thomas, Jessica Chenette, Jessica Gant, Alana Sterkel, Harjinder K. Ghuman, James Lute, Sandra C. Smole, Vaneet Arora, Courtney K. Demontigny, Meilan Bielby, Evelyn Geeter, Kimberly A.M. Newman, Mark Glazier, Whitney Lutkemeier, Megan Nelson, Raymond Martinez, Jasmine Chaitram, Margaret A. Honein, Julie M. Villanueva

Pathology and Lab Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

What is already known on this topic? The Laboratory Response Network (LRN) includes U.S. laboratories validated to perform the non-variola Orthopoxvirus (NVO) assay. What is added by this report? During May 17–June 30, 2022, LRN laboratories tested 2,009 specimens from patients with suspected monkeypox. Among these, 730 (36%) specimens from 395 patients were positive for NVO. Specimens from 159 persons with NVO-positive results were confirmed by CDC to be monkeypox; confirmatory testing is pending for 236. LRN laboratories have increased testing capacity from 8,000 per week in June because of NVO assay updates. What are the implications for public health practice? LRN laboratories’ rapid results enable prompt patient treatment and prevention of further transmission. Expansion of testing to five large national laboratories will increase ease of access to testing.

Original language	English
Pages (from-to)	904-907
Number of pages	4
Journal	Morbidity and Mortality Weekly Report
Volume	71
Issue number	28
DOIs	https://doi.org/10.15585/mmwr.mm7128e1
State	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022

Funding

Laboratory scientists and directors, public health and U.S. Department of Defense laboratories with LRN testing capability; team members, CDC Division of Preparedness and Emerging Infections Laboratory Preparedness and Response Branch; Center for Preparedness and Response, CDC; Division of Laboratory Systems, Center for Surveillance, Epidemiology, and Laboratory Systems/LRN Data Exchange Team, CDC; 2022 Monkeypox Response; Food and Drug Administration.

Funders
CDC Division of Preparedness
U.S. Department of Defense
Centers for Disease Control and Prevention
U.S. Food and Drug Administration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Epidemiology
Health(social science)
Health Information Management
Health, Toxicology and Mutagenesis

Access to Document

10.15585/mmwr.mm7128e1

Cite this

Aden, T. A., Blevins, P., York, S. W., Rager, S., Balachandran, D., Hutson, C. L., Lowe, D., Mangal, C. N., Wolford, T., Matheny, A., Davidson, W., Wilkins, K., Cook, R., Roulo, R. M., White, M. K., Berman, L. S., Murray, J., Laurance, J., Francis, D., ... Villanueva, J. M. (2022). Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022. Morbidity and Mortality Weekly Report, 71(28), 904-907. https://doi.org/10.15585/mmwr.mm7128e1

@article{1b932d237a5244c590152b9cae703086,

title = "Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022",

abstract = "What is already known on this topic? The Laboratory Response Network (LRN) includes U.S. laboratories validated to perform the non-variola Orthopoxvirus (NVO) assay. What is added by this report? During May 17–June 30, 2022, LRN laboratories tested 2,009 specimens from patients with suspected monkeypox. Among these, 730 (36\%) specimens from 395 patients were positive for NVO. Specimens from 159 persons with NVO-positive results were confirmed by CDC to be monkeypox; confirmatory testing is pending for 236. LRN laboratories have increased testing capacity from 8,000 per week in June because of NVO assay updates. What are the implications for public health practice? LRN laboratories{\textquoteright} rapid results enable prompt patient treatment and prevention of further transmission. Expansion of testing to five large national laboratories will increase ease of access to testing.",

author = "Aden, \{Tricia A.\} and Patricia Blevins and York, \{Shannon Whitman\} and Stacy Rager and Devika Balachandran and Hutson, \{Christina L.\} and David Lowe and Mangal, \{Chris N.\} and Tyler Wolford and Audrey Matheny and Whitni Davidson and Kimberly Wilkins and Rachael Cook and Roulo, \{Rebecca M.\} and White, \{Michael K.\} and Berman, \{La Shondra\} and Janna{\textquoteright} Murray and John Laurance and Drew Francis and Green, \{Nicole M.\} and Berumen, \{Ricardo A.\} and Anthony Gonzalez and Stacy Evans and Meghan Hudziec and Diane Noel and Michael Adjei and Gregory Hovan and Phil Lee and Lisa Tate and Gose, \{Remedios B.\} and Robert Voermans and Jennifer Crew and Adam, \{Phillip R.\} and Danielle Haydel and Salimatu Lukula and Nick Matluk and Sandip Shah and Joshua Featherston and Daphne Ware and Denise Pettit and Emily McCutchen and Edward Acheampong and Erin Buttery and Andrew Gorzalski and Michael Perry and Randal Fowler and Lee, \{Robert B.\} and Robert Nickla and Richard Huard and Amanda Moore and Katie Jones and Renee Johnson and Erin Swaney and Juan Jaramillo and Webb, \{Cynthia Reinoso\} and Brandon Guin and Janine Yost and Annette Atkinson and Latoya Griffin-Thomas and Jessica Chenette and Jessica Gant and Alana Sterkel and Ghuman, \{Harjinder K.\} and James Lute and Smole, \{Sandra C.\} and Vaneet Arora and Demontigny, \{Courtney K.\} and Meilan Bielby and Evelyn Geeter and Newman, \{Kimberly A.M.\} and Mark Glazier and Whitney Lutkemeier and Megan Nelson and Raymond Martinez and Jasmine Chaitram and Honein, \{Margaret A.\} and Villanueva, \{Julie M.\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

doi = "10.15585/mmwr.mm7128e1",

language = "English",

volume = "71",

pages = "904--907",

number = "28",

}

Aden, TA, Blevins, P, York, SW, Rager, S, Balachandran, D, Hutson, CL, Lowe, D, Mangal, CN, Wolford, T, Matheny, A, Davidson, W, Wilkins, K, Cook, R, Roulo, RM, White, MK, Berman, LS, Murray, J, Laurance, J, Francis, D, Green, NM, Berumen, RA, Gonzalez, A, Evans, S, Hudziec, M, Noel, D, Adjei, M, Hovan, G, Lee, P, Tate, L, Gose, RB, Voermans, R, Crew, J, Adam, PR, Haydel, D, Lukula, S, Matluk, N, Shah, S, Featherston, J, Ware, D, Pettit, D, McCutchen, E, Acheampong, E, Buttery, E, Gorzalski, A, Perry, M, Fowler, R, Lee, RB, Nickla, R, Huard, R, Moore, A, Jones, K, Johnson, R, Swaney, E, Jaramillo, J, Webb, CR, Guin, B, Yost, J, Atkinson, A, Griffin-Thomas, L, Chenette, J, Gant, J, Sterkel, A, Ghuman, HK, Lute, J, Smole, SC, Arora, V, Demontigny, CK, Bielby, M, Geeter, E, Newman, KAM, Glazier, M, Lutkemeier, W, Nelson, M, Martinez, R, Chaitram, J, Honein, MA & Villanueva, JM 2022, 'Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022', Morbidity and Mortality Weekly Report, vol. 71, no. 28, pp. 904-907. https://doi.org/10.15585/mmwr.mm7128e1

TY - JOUR

T1 - Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022

AU - Aden, Tricia A.

AU - Blevins, Patricia

AU - York, Shannon Whitman

AU - Rager, Stacy

AU - Balachandran, Devika

AU - Hutson, Christina L.

AU - Lowe, David

AU - Mangal, Chris N.

AU - Wolford, Tyler

AU - Matheny, Audrey

AU - Davidson, Whitni

AU - Wilkins, Kimberly

AU - Cook, Rachael

AU - Roulo, Rebecca M.

AU - White, Michael K.

AU - Berman, La Shondra

AU - Murray, Janna’

AU - Laurance, John

AU - Francis, Drew

AU - Green, Nicole M.

AU - Berumen, Ricardo A.

AU - Gonzalez, Anthony

AU - Evans, Stacy

AU - Hudziec, Meghan

AU - Noel, Diane

AU - Adjei, Michael

AU - Hovan, Gregory

AU - Lee, Phil

AU - Tate, Lisa

AU - Gose, Remedios B.

AU - Voermans, Robert

AU - Crew, Jennifer

AU - Adam, Phillip R.

AU - Haydel, Danielle

AU - Lukula, Salimatu

AU - Matluk, Nick

AU - Shah, Sandip

AU - Featherston, Joshua

AU - Ware, Daphne

AU - Pettit, Denise

AU - McCutchen, Emily

AU - Acheampong, Edward

AU - Buttery, Erin

AU - Gorzalski, Andrew

AU - Perry, Michael

AU - Fowler, Randal

AU - Lee, Robert B.

AU - Nickla, Robert

AU - Huard, Richard

AU - Moore, Amanda

AU - Jones, Katie

AU - Johnson, Renee

AU - Swaney, Erin

AU - Jaramillo, Juan

AU - Webb, Cynthia Reinoso

AU - Guin, Brandon

AU - Yost, Janine

AU - Atkinson, Annette

AU - Griffin-Thomas, Latoya

AU - Chenette, Jessica

AU - Gant, Jessica

AU - Sterkel, Alana

AU - Ghuman, Harjinder K.

AU - Lute, James

AU - Smole, Sandra C.

AU - Arora, Vaneet

AU - Demontigny, Courtney K.

AU - Bielby, Meilan

AU - Geeter, Evelyn

AU - Newman, Kimberly A.M.

AU - Glazier, Mark

AU - Lutkemeier, Whitney

AU - Nelson, Megan

AU - Martinez, Raymond

AU - Chaitram, Jasmine

AU - Honein, Margaret A.

AU - Villanueva, Julie M.

PY - 2022

Y1 - 2022

N2 - What is already known on this topic? The Laboratory Response Network (LRN) includes U.S. laboratories validated to perform the non-variola Orthopoxvirus (NVO) assay. What is added by this report? During May 17–June 30, 2022, LRN laboratories tested 2,009 specimens from patients with suspected monkeypox. Among these, 730 (36%) specimens from 395 patients were positive for NVO. Specimens from 159 persons with NVO-positive results were confirmed by CDC to be monkeypox; confirmatory testing is pending for 236. LRN laboratories have increased testing capacity from 8,000 per week in June because of NVO assay updates. What are the implications for public health practice? LRN laboratories’ rapid results enable prompt patient treatment and prevention of further transmission. Expansion of testing to five large national laboratories will increase ease of access to testing.

AB - What is already known on this topic? The Laboratory Response Network (LRN) includes U.S. laboratories validated to perform the non-variola Orthopoxvirus (NVO) assay. What is added by this report? During May 17–June 30, 2022, LRN laboratories tested 2,009 specimens from patients with suspected monkeypox. Among these, 730 (36%) specimens from 395 patients were positive for NVO. Specimens from 159 persons with NVO-positive results were confirmed by CDC to be monkeypox; confirmatory testing is pending for 236. LRN laboratories have increased testing capacity from 8,000 per week in June because of NVO assay updates. What are the implications for public health practice? LRN laboratories’ rapid results enable prompt patient treatment and prevention of further transmission. Expansion of testing to five large national laboratories will increase ease of access to testing.

UR - https://www.scopus.com/pages/publications/85134431339

UR - https://www.scopus.com/pages/publications/85134431339#tab=citedBy

U2 - 10.15585/mmwr.mm7128e1

DO - 10.15585/mmwr.mm7128e1

M3 - Article

C2 - 35834423

AN - SCOPUS:85134431339

SN - 0149-2195

VL - 71

SP - 904

EP - 907

JO - Morbidity and Mortality Weekly Report

JF - Morbidity and Mortality Weekly Report

IS - 28

ER -

Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, United States, May 17–June 30, 2022

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

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