Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking

Neringa M. Stankeviciute; Michael D. Scofield; Peter W. Kalivas; Cassandra D. Gipson

doi:10.1111/adb.12064

Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking

Neringa M. Stankeviciute
, Michael D. Scofield
, Peter W. Kalivas
, Cassandra D. Gipson

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.

Original language	English
Pages (from-to)	972-974
Number of pages	3
Journal	Addiction Biology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1111/adb.12064
State	Published - Nov 1 2014

Bibliographical note

Publisher Copyright:
© 2013 Society for the Study of Addiction.

Funding

Funders

Funder number

National Institutes of Health (NIH)

DA03906, DA012513, DA015369, DA033690

Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse

P50DA015369, R01DA012513, F32DA033690, R01DA003906

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cocaine
context-induced relapse
dendritic spines
nucleus accumbens core
synaptic potentiation

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology
Psychiatry and Mental health

Access to Document

10.1111/adb.12064

Cite this

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title = "Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking",

abstract = "Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.",

keywords = "Cocaine, context-induced relapse, dendritic spines, nucleus accumbens core, synaptic potentiation",

author = "Stankeviciute, \{Neringa M.\} and Scofield, \{Michael D.\} and Kalivas, \{Peter W.\} and Gipson, \{Cassandra D.\}",

note = "Publisher Copyright: {\textcopyright} 2013 Society for the Study of Addiction.",

year = "2014",

month = nov,

day = "1",

doi = "10.1111/adb.12064",

language = "English",

volume = "19",

pages = "972--974",

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}

TY - JOUR

T1 - Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking

AU - Stankeviciute, Neringa M.

AU - Scofield, Michael D.

AU - Kalivas, Peter W.

AU - Gipson, Cassandra D.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.

AB - Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.

KW - Cocaine

KW - context-induced relapse

KW - dendritic spines

KW - nucleus accumbens core

KW - synaptic potentiation

UR - https://www.scopus.com/pages/publications/84916238125

UR - https://www.scopus.com/pages/publications/84916238125#tab=citedBy

U2 - 10.1111/adb.12064

DO - 10.1111/adb.12064

M3 - Article

C2 - 23648005

AN - SCOPUS:84916238125

SN - 1355-6215

VL - 19

SP - 972

EP - 974

JO - Addiction Biology

JF - Addiction Biology

IS - 6

ER -

Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this