Ras family small GTPase-mediated neuroprotective signaling in stroke

Geng Xian Shi, Douglas A. Andres, Weikang Cai

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Selective neuronal cell death is one of the major causes of neuronal damage following stroke, and cerebral cells naturally mobilize diverse survival signaling pathways to protect against ischemia. Importantly, therapeutic strategies designed to improve endogenous anti-apoptotic signaling appear to hold great promise in stroke treatment. While a variety of complex mechanisms have been implicated in the pathogenesis of stroke, the overall mechanisms governing the balance between cell survival and death are not well-defined. Ras family small GTPases are activated following ischemic insults, and in turn, serve as intrinsic switches to regulate neuronal survival and regeneration. Their ability to integrate diverse intracellular signal transduction pathways makes them critical regulators and potential therapeutic targets for neuronal recovery after stroke. This article highlights the contribution of Ras family GTPases to neuroprotective signaling cascades, including mitogen-activated protein kinase (MAPK) family protein kinase- and AKT/PKB-dependent signaling pathways as well as the regulation of cAMP response element binding (CREB), Forkhead box O (FoxO) and hypoxiainducible factor 1(HIF1) transcription factors, in stroke.

Original languageEnglish
Pages (from-to)114-137
Number of pages24
JournalCentral Nervous System Agents in Medicinal Chemistry
Issue number2
StatePublished - Jun 2011


  • Cell death
  • Cell survival
  • Ischemia
  • Neuroprotection
  • Ras family GTPases
  • Signal transduction
  • Stroke
  • Transcription factors

ASJC Scopus subject areas

  • Neuroscience (all)
  • Neuropsychology and Physiological Psychology
  • Molecular Medicine


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