Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka; Morris Pollard; Mark Suckow; Wojciech P. Mielicki; Elliot D. Rosen

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka, Morris Pollard, Mark Suckow, Wojciech P. Mielicki, Elliot D. Rosen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

Original language	English
Pages (from-to)	282-286
Number of pages	5
Journal	Comparative Medicine
Volume	58
Issue number	3
State	Published - Jun 2008

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)
Veterinary (all)

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Cite this

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title = "Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X",

abstract = "Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.",

author = "Malgorzata Kamocka and Morris Pollard and Mark Suckow and Mielicki, {Wojciech P.} and Rosen, {Elliot D.}",

year = "2008",

month = jun,

language = "English",

volume = "58",

pages = "282--286",

number = "3",

}

TY - JOUR

T1 - Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

AU - Kamocka, Malgorzata

AU - Pollard, Morris

AU - Suckow, Mark

AU - Mielicki, Wojciech P.

AU - Rosen, Elliot D.

PY - 2008/6

Y1 - 2008/6

N2 - Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

AB - Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

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UR - http://www.scopus.com/inward/citedby.url?scp=46849087407&partnerID=8YFLogxK

M3 - Article

C2 - 18589871

AN - SCOPUS:46849087407

SN - 1532-0820

VL - 58

SP - 282

EP - 286

JO - Comparative Medicine

JF - Comparative Medicine

IS - 3

ER -

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Abstract

ASJC Scopus subject areas

UN SDGs

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