Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

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4 Scopus citations

Abstract

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Original languageEnglish
Pages (from-to)568-574
Number of pages7
JournalPancreas
Volume51
Issue number6
DOIs
StatePublished - Jul 1 2022

Bibliographical note

Funding Information:
The study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) under award numbers U01 DK127367 (G.T., M.B.), U01 DK127377 (A.E.P., F.G.S.T., D.Y.), U01 DK127378 (C.Y.), U01 DK127382 (J.J.E., E.F., T.T.), U01 DK127384 (A.M.D., V.C., J.L.M., M.W.), U01 DK127388 (P.A.H., G.I.P., D.L.C., K.M.D., P.J.L.), U01 DK127392 (C.F.), U01 DK127395 (W.J.P.), U01 DK127400 (E.A., V.A., R.R.K., V.S., A.Z.), U01 DK127403 (J.B., M.K., S.J.P., S.S.V.), and U01 DK127404 (C.G., R.K., C.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • AP - acute pancreatitis
  • CP - chronic pancreatitis
  • DCC - data coordinating center
  • DM - diabetes mellitus
  • DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms
  • FSIGTT - frequently sampled intravenous glucose tolerance testing
  • MMTT - mixed meal tolerance testing
  • OGTT - oral glucose tolerance testing
  • T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium
  • autoantibody
  • beta cell
  • epidemiology
  • insulin
  • pancreatogenic diabetes
  • type 3c diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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