TY - JOUR
T1 - Reaching Out to Send a Message
T2 - Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat
AU - Triplett, Judy C.
AU - Swomley, Aaron M.
AU - Kirk, Jessime
AU - Grimes, Kelly M.
AU - Lewis, Kaitilyn N.
AU - Orr, Miranda E.
AU - Rodriguez, Karl A.
AU - Cai, Jian
AU - Klein, Jon B.
AU - Buffenstein, Rochelle
AU - Butterfield, D. Allan
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1. We hypothesize that such changes may contribute to the extended lifespan and healthspan of the NMR.
AB - Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1. We hypothesize that such changes may contribute to the extended lifespan and healthspan of the NMR.
KW - Aging
KW - Naked mole-rat
KW - Neurite outgrowth
KW - Neurotransmission
KW - Phosphoproteomics
KW - Proteomics
UR - http://www.scopus.com/inward/record.url?scp=84959540117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959540117&partnerID=8YFLogxK
U2 - 10.1007/s11064-016-1877-1
DO - 10.1007/s11064-016-1877-1
M3 - Article
C2 - 26935741
AN - SCOPUS:84959540117
SN - 0364-3190
VL - 41
SP - 1625
EP - 1634
JO - Neurochemical Research
JF - Neurochemical Research
IS - 7
ER -