Reactive oxygen species and molecular mechanism of silica-induced lung injury

X. Shi, M. Ding, F. Chen, L. Wang, Y. Rojanasakul, V. Vallyathan, V. Castranova

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Silica particles are considered to be fibrogenic and carcinogenic agents, but the mechanisms of disease initiation and progression are not fully understood. This article summarizes the literature on the generation of reactive oxygen species (ROS) directly from interaction of silica with aqueous medium and from silicastimulated cells. This article also discusses the role of ROS in silica-induced lung injury, with particular focus on the silica-induced NF-κB activation, including the molecular mechanisms of its regulation, its possible attenuation, and its relationship to silica-induced generation of cyclooxygenase II and TNF-α.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalJournal of Environmental Pathology, Toxicology and Oncology
Issue numberSUPPL. 1
StatePublished - 2001


  • Cyclooxygenase II
  • Free radicals
  • NF-κB
  • Reactive oxygen species
  • Silicosis
  • TNF-α

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis


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