Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate

Sergei V. Makarov; Claudius Mundoma; Serge A. Svarovsky; X. Shi; P. M. Gannett; Reuben H. Simoyi

doi:10.1006/abbi.1999.1264

Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate

Sergei V. Makarov, Claudius Mundoma, Serge A. Svarovsky, X. Shi, P. M. Gannett, Reuben H. Simoyi

Toxicology and Cancer Biology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Sodium hydroxymethanesulfinate, (HOCH₂SO₂Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S₂O^2-₄, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S₂O^2-₄. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO^-₃. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS.

Original language	English
Pages (from-to)	289-296
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	367
Issue number	2
DOIs	https://doi.org/10.1006/abbi.1999.1264
State	Published - Jul 15 1999

Bibliographical note

Funding Information:
We thank the Ivanovo Academy of Chemistry and Technology for giving a leave of absence to S.V.M. S.V.M. is grateful to the Russian Foundation for Basic Research for financial support (Grant No. 98-03-32802). C.M. is grateful to Steve Leonard for helping with ESR experiments. This work was sponsored by the National Science Foundation (Grant No. CHE-9632592).

Funding

We thank the Ivanovo Academy of Chemistry and Technology for giving a leave of absence to S.V.M. S.V.M. is grateful to the Russian Foundation for Basic Research for financial support (Grant No. 98-03-32802). C.M. is grateful to Steve Leonard for helping with ESR experiments. This work was sponsored by the National Science Foundation (Grant No. CHE-9632592).

Funders	Funder number
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China	CHE-9632592
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China
Russian Foundation for Basic Research	98-03-32802
Russian Foundation for Basic Research

Keywords

Aminoiminomethanesulfinic acid
Hydroxymethanesulfinate
Reactive oxygen species
Sulfite radical ion
Sulfoxylate ion
Sulfur dioxide radical ion
Thioureas oxides

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1006/abbi.1999.1264

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title = "Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate",

abstract = "Sodium hydroxymethanesulfinate, (HOCH2SO2Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S2O2-4, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S2O2-4. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO-3. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS.",

keywords = "Aminoiminomethanesulfinic acid, Hydroxymethanesulfinate, Reactive oxygen species, Sulfite radical ion, Sulfoxylate ion, Sulfur dioxide radical ion, Thioureas oxides",

author = "Makarov, \{Sergei V.\} and Claudius Mundoma and Svarovsky, \{Serge A.\} and X. Shi and Gannett, \{P. M.\} and Simoyi, \{Reuben H.\}",

note = "Funding Information: We thank the Ivanovo Academy of Chemistry and Technology for giving a leave of absence to S.V.M. S.V.M. is grateful to the Russian Foundation for Basic Research for financial support (Grant No. 98-03-32802). C.M. is grateful to Steve Leonard for helping with ESR experiments. This work was sponsored by the National Science Foundation (Grant No. CHE-9632592).",

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doi = "10.1006/abbi.1999.1264",

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AU - Makarov, Sergei V.

AU - Mundoma, Claudius

AU - Svarovsky, Serge A.

AU - Shi, X.

AU - Gannett, P. M.

AU - Simoyi, Reuben H.

N1 - Funding Information: We thank the Ivanovo Academy of Chemistry and Technology for giving a leave of absence to S.V.M. S.V.M. is grateful to the Russian Foundation for Basic Research for financial support (Grant No. 98-03-32802). C.M. is grateful to Steve Leonard for helping with ESR experiments. This work was sponsored by the National Science Foundation (Grant No. CHE-9632592).

PY - 1999/7/15

Y1 - 1999/7/15

N2 - Sodium hydroxymethanesulfinate, (HOCH2SO2Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S2O2-4, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S2O2-4. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO-3. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS.

AB - Sodium hydroxymethanesulfinate, (HOCH2SO2Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S2O2-4, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S2O2-4. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO-3. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS.

KW - Aminoiminomethanesulfinic acid

KW - Hydroxymethanesulfinate

KW - Reactive oxygen species

KW - Sulfite radical ion

KW - Sulfoxylate ion

KW - Sulfur dioxide radical ion

KW - Thioureas oxides

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AN - SCOPUS:0033566124

SN - 0003-9861

VL - 367

SP - 289

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JO - Archives of Biochemistry and Biophysics

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IS - 2

ER -

Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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