Realizing the clinical utility of saliva for monitoring oral diseases

Jeffrey L. Ebersole, Hatice Hasturk, Michaell Huber, Robert Gellibolian, Adam Markaryan, Xiaohua D. Zhang, Craig S. Miller

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In the era of personalized/precision health care, additional effort is being expended to understand the biology and molecular mechanisms of disease processes. How these mechanisms are affected by individual genetics, environmental exposures, and behavioral choices will encompass an expanding role in the future of optimally preventing and treating diseases. Considering saliva as an important biological fluid for analysis to inform oral disease detection/description continues to expand. This review provides an overview of saliva as a diagnostic fluid and the features of various biomarkers that have been reported. We emphasize the use of salivary biomarkers in periodontitis and transport the reader through extant literature, gaps in knowledge, and a structured approach toward validating and determine the utility of biomarkers in periodontitis. A summation of the findings support the likelihood that a panel of biomarkers including both host molecules and specific microorganisms will be required to most effectively identify risk for early transition to disease, ongoing disease activity, progression, and likelihood of response to standard periodontal therapy. The goals would be to develop predictive algorithms that serve as adjunctive diagnostic tools which provide the clinician and patient important information for making informed clinical decisions.

Original languageEnglish
Pages (from-to)203-219
Number of pages17
JournalPeriodontology 2000
Volume95
Issue number1
DOIs
StatePublished - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords

  • biomarkers
  • periodontitis
  • saliva

ASJC Scopus subject areas

  • Periodontics

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