Recent advances in the analysis of phenothilazine drugs and their metabolites using high performance liquid chromatography

G. Mckay; J. Geddes; M. J. Cowper; T. S. Gurnsey

doi:10.1016/0278-5846(83)90049-0

Recent advances in the analysis of phenothilazine drugs and their metabolites using high performance liquid chromatography

G. Mckay, J. Geddes, M. J. Cowper, T. S. Gurnsey

Neuroscience

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

1. 1. HPLC procedures with electrochemical or ultraviolet detection were developed in order to analyze plasma samples from patients and volunteers who had received antipsychotic drugs. 2. 2. Procedures were described for the determination of chlorpromazine and trimeprazine in human plasma. 3. 3. The described procedures for chlorpromazine and trimeprazine demonstrated sufficient sensitivity for their use in pharmacokinetic studies following low single oral doses of these agents. 4. 4. The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radiolmmunoassay procedures, respectively.

Original language	English
Pages (from-to)	703-707
Number of pages	5
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	7
Issue number	4-6
DOIs	https://doi.org/10.1016/0278-5846(83)90049-0
State	Published - 1983

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

HPLC
antipsychotic drugs
chlorpromazine
thioridazine
trimeprazine

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/0278-5846(83)90049-0

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abstract = "1. 1. HPLC procedures with electrochemical or ultraviolet detection were developed in order to analyze plasma samples from patients and volunteers who had received antipsychotic drugs. 2. 2. Procedures were described for the determination of chlorpromazine and trimeprazine in human plasma. 3. 3. The described procedures for chlorpromazine and trimeprazine demonstrated sufficient sensitivity for their use in pharmacokinetic studies following low single oral doses of these agents. 4. 4. The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radiolmmunoassay procedures, respectively.",

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author = "G. Mckay and J. Geddes and Cowper, {M. J.} and Gurnsey, {T. S.}",

year = "1983",

doi = "10.1016/0278-5846(83)90049-0",

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T1 - Recent advances in the analysis of phenothilazine drugs and their metabolites using high performance liquid chromatography

AU - Mckay, G.

AU - Geddes, J.

AU - Cowper, M. J.

AU - Gurnsey, T. S.

PY - 1983

Y1 - 1983

N2 - 1. 1. HPLC procedures with electrochemical or ultraviolet detection were developed in order to analyze plasma samples from patients and volunteers who had received antipsychotic drugs. 2. 2. Procedures were described for the determination of chlorpromazine and trimeprazine in human plasma. 3. 3. The described procedures for chlorpromazine and trimeprazine demonstrated sufficient sensitivity for their use in pharmacokinetic studies following low single oral doses of these agents. 4. 4. The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radiolmmunoassay procedures, respectively.

AB - 1. 1. HPLC procedures with electrochemical or ultraviolet detection were developed in order to analyze plasma samples from patients and volunteers who had received antipsychotic drugs. 2. 2. Procedures were described for the determination of chlorpromazine and trimeprazine in human plasma. 3. 3. The described procedures for chlorpromazine and trimeprazine demonstrated sufficient sensitivity for their use in pharmacokinetic studies following low single oral doses of these agents. 4. 4. The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radiolmmunoassay procedures, respectively.

KW - HPLC

KW - antipsychotic drugs

KW - chlorpromazine

KW - thioridazine

KW - trimeprazine

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SN - 0278-5846

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JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 4-6

ER -

Recent advances in the analysis of phenothilazine drugs and their metabolites using high performance liquid chromatography

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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