Recent advances in the analysis of phenothilazine drugs and their metabolites using high performance liquid chromatography

G. Mckay, J. Geddes, M. J. Cowper, T. S. Gurnsey

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

1. 1. HPLC procedures with electrochemical or ultraviolet detection were developed in order to analyze plasma samples from patients and volunteers who had received antipsychotic drugs. 2. 2. Procedures were described for the determination of chlorpromazine and trimeprazine in human plasma. 3. 3. The described procedures for chlorpromazine and trimeprazine demonstrated sufficient sensitivity for their use in pharmacokinetic studies following low single oral doses of these agents. 4. 4. The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radiolmmunoassay procedures, respectively.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume7
Issue number4-6
DOIs
StatePublished - 1983

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • HPLC
  • antipsychotic drugs
  • chlorpromazine
  • thioridazine
  • trimeprazine

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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